3DS work resulted in 2022 in a total of 5 book chapters and 69 papers indexed to the Web of Science, with an average impact factor of 4.945. From these, 42% were published in journals in the 1st quartile of the JCR journal ranking (4 in the top decile). One national patent was granted. One student was awarded with a PhD FCT fellowships and three others finished the PhD degree in Pharmaceutical Sciences. Fourteen students were awarded with Msc degree.
Five main publications:
1) Lima E, Barroso AG, Sousa MA, Ferreira O, Boto RE, Fernandes JR, Almeida P, Silvestre SM, Santos AO, Reis LV. Picolylamine-functionalized benz[e]indole squaraine dyes: Synthetic approach, characterization and in vitro efficacy as potential anticancer phototherapeutic agents. Eur J Med Chem. 2022; 229: 114071. https://doi.org/10.1016/j.ejmech.2021.114071 (IF: 7.008. Q1 D1. Chemistry, Analytical).
Justification: In this work were discovered novel candidate anticancer agents with high in vitro efficacy.
2) Cruz-Vicente P, Gonçalves AM, Ferreira O, Queiroz JA, Silvestre S, Passarinha LA, Gallardo E. Discovery of Small Molecules as Membrane-Bound Catechol-O-methyltransferase Inhibitors with Interest in Parkinson’s Disease: Pharmacophore Modeling, Molecular Docking and In Vitro Experimental Validation Studies. Pharmaceuticals. 2022; 15(1):51. https://doi.org/10.3390/ph15010051 (IF:5.125. Q1 Pharmacology & Pharmacy; Q2 Chemistry, Medicinal)
Justification: In this work were discovered novel inhibitors of the membrane-bound Catechol-O-methyltransferase (a drug target in Parkinsion’s Disease).
3) Brinca AT, Anjos O, Alves MMC, Sousa Â, Oliani AH, Breitenfeld L, Passarinha LA, Ramalhinho AC, Gallardo E. Volatilomics as an Emerging Strategy to Determine Potential Biomarkers of Female Infertility: A Pilot Study. Biomedicines 2022; 10(11): 2852. https://doi.org/10.3390/biomedicines10112852 (IF: 4.757. Q2 Biochemistry & Molecular Biology, Q2 Medicine, Research & Experimental)
Justification: In this work were identified using volatilomics the potential biomarkers of female infertility.
4) Meirinho S, Rodrigues M, Ferreira CL, Oliveira RC, Fortuna A, Santos AO, Falcão A, Alves G. Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel. Int J pharmaceutics. 2022; 622: 121853. https://doi.org/10.1016/j.ijpharm.2022.121853 (IF: 6.510. Q1. Pharmacology & Pharmacy).
Justification: In this work were developed novel efficient delivery strategy (intranasal nanosystem) for the antiepileptic perampanel.
5) Rodrigues DA, Plácido AI, Mateos-Campos R, Figueiras A, Herdeiro MT, Roque F. Effectiveness of Interventions to Reduce Potentially Inappropriate Medication in Older Patients: A Systematic Review. Front Pharmacol. 2022; 12: 777655. https://doi.org/10.3389/fphar.2021.777655 (IF: 5.988. Q1. Pharmacology & Pharmacy)
Justification: In this work were evidenced interventions in the community that contribute to the reduction of potentially inappropriate medication in older patients.