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Pharmaceutical Organic Chemistry

Pharmaceutical Organic Chemistry

Code	13429
Year	3
Semester	S2
ECTS Credits	6
Workload	PL(30H)/T(30H)
Scientific area	Biomedical Sciences
Mode of delivery	Presence with e-learning
Learning outcomes	To complement the studies in Organic Chemistry. To study the concept of protecting group. To analyse heterocyclic compounds. To apply the concept of retrosynthesis. To acquire knowledge about the molecular basis of drug discovery, design, development and action. At the end of this course unit the student should be able to: realize that it is possible perform certain reactions using protecting groups; know the methods of analysis of molecules from the target molecule and able to search for the simpler molecules for the synthesis. Identify the different heterocyclic compounds; apply current strategies for the discovery and development of leads; predict the effects of the chemical characteristics of drugs in their pharmacokinetics; evaluate and interpret structure-activity relationships; predict drug interactions with biological targets and the underlying molecular mechanisms.
Syllabus	Theorical classes Chapter 1 PHENOLS Chapter 2 AMINES AND DERIVATIVES Chapter 3 PROTECTING GROUPS Chapter 4 RETROSYNTHESIS Chapter 5 HETEROCYCLIC COMPOUNDS Aromatics Non aromatic compound Chapter 6 INTRODUCTION TO PHARMACEUTICAL CHEMISTRY Chapter 7 DRUG DISCOVERY, DESIGN AND DEVELOPMENT Lead discovery and modification Qualitative and quantitative structure-activity relationships Computer-assisted drug-design Prodrugs Chapter 8 DRUG INTERACTION WITH RECEPTORS Chapter 9 DRUG INTERACTION WITH ENZYMES Laboratory classes 1 Introduction 2 Reactions of protection of functional groups 3 Electrophilic aromatic substitution reactions 4 Preparation of heterocyclic compounds (2 classes) 5 Problems classes (2 classes) 6 Identification and quantification of drugs (3 classes) 7 Stereoselective reactions 8 Gastrointestinal absorption of drugs and preparation of prodrugs (2 classes) 9 Discussion of reports (2 classes)
Main Bibliography	1. T. W. G. Solomons, G. B. Fryhle, Organic Chemistry, 10th Ed., J. Wiley & Sons, Inc., USA, 2010. 2. F. A. Carey, Organic Chemistry, 9th Ed., Mc Graw Hill, N. Y., 2013. 3. T. W. Greene, P. G. M. Wuts, Protective Groups in Organic Synthesis, 3rd Ed., J. Wiley & Sons, Inc., USA, 1999. 1. R. B. Silverman, The Organic Chemistry of Drug Design and Drug Action, 2nd Ed., Elsevier Academic Press, 2004; 4. G. L. Patrick, An Introduction to Medicinal Chemistry, 5th Ed., Oxford University Press, 2013; 5. C. Avendaño, Introducción a la Química Farmacéutica, 2ª Ed., Mc.Graw-Hill, 2001; 6. http://old.iupac.org/publications/cd/medicinal_chemistry/
Language	Portuguese. Tutorial support is available in English.