Pharmacognosia II

Code	13646
Year	2
Semester	S1
ECTS Credits	6
Workload	PL(30H)/T(30H)
Scientific area	Ciências Farmacêuticas
Entry requirements	N/A
Mode of delivery	Face-to-face.
Work placements	Not applicable.
Learning outcomes	In this course unit it is intended that the student identifies the chemical constituents of the secondary metabolism of medicinal plants and relate this compounds to their chemical and biological properties. At the end of the course unit the student should be able to identify and relate the chemical constituents of the secondary metabolism of medicinal plants with their chemical and biological properties. To identify the different groups of compounds of the secondary metabolism of the plants and understand their distribution in nature, extraction methods, quality control, chemical structure and structure-activity interaction.
Syllabus	Theoretical: 1. Phenolic compounds: Phenolic acids; Coumarins;Lignans; Stilbenes; Flavonoids; Curcuminoids; Tannins; quinonic compounds; orcinols and phloroglucinols 2. Terpenoids and steroids: essential oils; Iridoids; Diterpenes; Saponosides and Cardiotonics; Carotenoids 3. Alkaloids: Distribution and location; Main biological activities and therapeutic uses; Classification and important examples: Alkaloids with an amine group in the side chain; Alkaloids with pyrrolidine, pyridine and piperidine nuclei; Alkaloids with a tropane nucleus; Alkaloids with a pyrrolizidine nucleus; Alkaloids with quinolizidine nucleus; Quinoline alkaloids; Alkaloids with isoquinoline; Alkaloids with an indole nucleus; Alkaloids derived from terpene metabolism (diterpene alkaloids and steroids); other alkaloids. Methylxanthines.
Main Bibliography	Pharmacognosie, phytochimie, plantes médicinales, Bruneton, J., Editions Techniques et Documentation, 4eme edition, 2009. Farmacognosia e fitoquímica , Proença da Cunha, A. (Ed.), Fundação Calouste Gulbenkian, 2005. Trease and Evans Pharmacognosy, Evans, W.C., Edinburgh: Saunders , 2002. Farmacopeia Portuguesa, 1º e 2º vol., 9ª Ed oficial, Ministério da Saúde, INFARMED, 2008. Farmacognosia - Farmacognosia experimental, Costa, A. F., Fundação Calouste Gulbenkian, 3ª ed., 2001.
Teaching Methodologies and Assessment Criteria	Lectures: 2 hours / week. Master classes with power point presentations with previous distribution to students. Laboratory classes: 2 hours / week. The protocols of the laboratory works and their theoretical explanation are distributed to students at the beginning of the semester. Students should work in groups of two. At the beginning of the semester it will be defined by the professor a schedule for tutorial hours for students (2 hours / week).Periodic evaluation: I. Written Evaluation: 2 partial tests (80% theoretical questions + 20% practical questions). II. Monograph on a free theme based on scientific articles with presentation. 2. Frequency criteria: Students must perform all laboratory works; Students must participate in all partial tests and obtain a minimum average score of 6 values to participate in the final exam; Final grade: Theoretical part (average of partial tests or classification of the final exam)(minimum grade: 9.0)(80%) + Monograph (20%).
Language	Portuguese. Tutorial support is available in English.