| Code |
15117
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| Year |
2
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| Semester |
A1
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| ECTS Credits |
6
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| Workload |
OT(46H)/PL(6H)/S(4H)
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| Scientific area |
Morphological and Functional Sciences
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Entry requirements |
None.
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Learning outcomes |
At the end of this course unit, students should me able to: 1) to correlate the hematopoiesis phases with the morphological and functional characteristics of blood cells, 2) to recognize the blood components and to diferentiate their actions in the organism, 3) distinguish the steps and mechanisms of hemostasis and coagulation. In what regards the Immune System (IS), the learning outcomes are: 1) to describe and integrate theknowledge about the organs, cells and molecules of the IS, its organization and diversity, as well as its specialized functions, namely the pathways involved in the induction and regulation of an inate and adaptative normal physiological response.
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Syllabus |
Blood (pedagogical unit 1): hematopoiesis, components and functions of the blood, and hemostasis.
Immune System (pedagogical units 2 and 3):
1. Dynamics of the SI
2. Components of the SI
3. Innate responses:
3.1. NK and phagocytic cells: characteristics, activation, and function
3.2 Inflammation and System of the Complement
4. Structure and function of MHC molecules and antigen presentation mechanisms pathways
5. Cellular immune responses: ontogeny and activation of T cells
5.1 phenotypical and functional aspects of T cell populations
6. Humoral immune responses: ontogeny and activation of B cells
6.1 Immunoglobulins (Igs): diversity, characteristics, functions, isotype changes, and affinity maturation
7. Central and peripheral immunological tolerance.
Practical classes consist of: morphological analysis of blood leucocytes in blood smear examination with microscopes, agglutination latex-based, and hemagglutination techniques, and histological identification of lymphoid organs.
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Main Bibliography |
Cellular and Molecular Immunology” Abul Abbas, Andrew H. Lichtman, Shiv Pillai. Elsevier (10ª ed; 2021)
“Saladin: Anatomy & Physiology: The Unity of Form and Function”; McGraw-Hill (8ª ed; 2018)
“Henry’s Clinical Diagnosis and Management by Laboratory Methods”; Richard A. McPherson, Matthew R. Pincus; Saunders / Elsevier (23ª ed; 2016);
“Hoffbrand´s Essential Haematology”; A.V. Hoffbrand, P.A.H. Moss; Artmed (7ª ed; 2016);
Essentials of Clinical Immunology, 6th Edition. Chapel H, Haeney M, Misbah S, Snowden N. Wiley-Blackwell
“Textbook of Medical Physiology”. Guyton and Hall; Saunders (12th ed.; 2016)
"Ross -Histologia Texto e Atlas 7ª Ed -2016
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Teaching Methodologies and Assessment Criteria |
In this course unit, student-centered teaching methodologies are adopted.
With the aim to promote the understanding of the relevance of the themes, the students discuss problems in groups and the discussion about their resolution is encouraged. In practical classes, the students have the opportunity to execute laboratory techniques relevant to the understanding of the Immune System components and mechanisms. In this context, the knowledge is assessed through written tests consisting of multiple-choice questions aligned with the proposed learning objectives.
Pedagogic Unit 1 test: 17,5%
Pedagogic Unit 2 test UP2: 17,5%
Pedagogic Unit 3 test: 17,5%
Global test: 42,5%
Profissional atitudes: 5%
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Language |
Portuguese. Tutorial support is available in English.
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