Outcomes

In line with the societal challenges and the Sustainable Developmental Goals of the UN 2030 Agenda, research carried out at CICS-UBI has contributed to the advancement of scientific knowledge with impact on diagnosis and treatment of several non-communicable diseases including cancer, endocrine and metabolic diseases, and neurologic and neurovascular disorders.

Publications

Ongoing Funded projects

BIOmedical DEVICE development based on pre-miRNA Gquadruplex, MIT Portugal Program (MITEXPL/BIO/0008/2017).

DRug dElivery nAnosysteM for HPV infection therapy, UTAustin-Portugal Program (UTAPEXPL/NTec/0015/2017).

Tribbles Research and Innovation Network (TRAIN), H2020/EU project ID 721532.

Interdisciplinary Challenges On Neurodegeneration (ICON), Programa Operacional Regional do Centro (CENTRO-01-0145-FEDER-000013).

Inovation with plant extracts: developing new pharmaceutical products, disruptive and technological advanced (Programa Operacional Regional do Centro, supported by FEDER - Sistema de Incentivos às Empresas, Investigação e Desenvolvimento Tecnológico – Projetos de I&D em Copromoção 033815).

CMeC - Cereja do Fundão confitada com mel e carqueja como promotora da saúde, Programa Operacional Regional do Centro (CENTRO-01-0247-FEDER-017547).

Characterization of the bioativitiy potential of mineral thermal waters from the center region of Portugal, CCDRC, Provere - Programa de Valorização das Estâncias Termais da Região Centro.

Clinical investigation in crenotherapy, molecular and clinical studies – effects of inhalation of sulfurous thermal water in patients with respiratory diseases, chronic rhinosinusitis and bronchial asthma, CCDRC, Provere - Programa de Valorização das Estâncias Termais da Região Centro.

Genetic risk factors for pituitary adenomas: a national, multicenter, genetic and clinical analysis, Fundação para a Ciência e a Tecnologia (POCI-01-0145-029489).
Ionic Liquid-based supports for pre-miRNAs purification targeting Alzheimer's disease, Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-029496).

IsChoHep - The Role of Ischaemic Cholangiopathy in Conditions of Hepatic Dysfunction, Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-028956).

New approaches on Hypoxic-Ischemic Encephalopathy: translational research to diagnose and monitor stem cell therapy, Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-029311).

Non-invasive ocular insert for drug delivery, Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-031462).

ProMETAB - Shaping prostate cell metabolism by extrinsic factors: insights into cancer prevention, diagnosis and treatment, Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-029114).

Towards the improvement of recombinant proteins bioprocessing using ionic liquids, Fundação para a Ciência e a Tecnologia (POCI-01-0145-FEDER-030840)

ZAPGO - Zwitterionic-based amphiphile coated Graphene Oxide nanostructures for chemophotothermal therapy of breast cancer, Fundação para a Ciência e a Tecnologia (POCI-01-0145-028989).

Pre-miRNAs for Alzheimer’s disease therapy: biosynthesis, purification and delivery, Acordo bilateral FCT-PHC ((Programa Pessoa) 2018-2019

G-quadruplex aptamers for cervical cancer therapy, Ações Integradas Luso-Francesas (TC-15/17).

Cell­based therapy for vascular and neurological repair in stroke, Fundação para a Ciência e a Tecnologia (IF/00178/2015).

Gene Therapy for Mitochondrial DNA disease: Development of a mitochondrial-targeted vector, Fundação para a Ciência e a Tecnologia (IF/01459/2015).

Nucleolin targeting by G-quadruplex aptamers for cervical cancer therapy, Fundação para a
Ciência e a Tecnologia (IF/00959/2015).

Development and characterization of smart micelleplexes for lung cancer therapy, Fundação para a Ciência e a Tecnologia (PTDC/CTMBIO/1518/2014).

Luminescent electrochromic devices incorporating organic/inorganic (bio)hybrid electrolytes, Fundação para a Ciência e a Tecnologia (PTDC/CTMNAN/0956/2014).

Obesitility – Gut hormones and testicular metabolism: mechanisms associated with obesityrelated male infertility, Fundação para a Ciência e a Tecnologia (PTDC/BIM-MET/4712/2014).

Relationship between adenosine and chromosomal instability: a new perspective to understand the oncogenic mechanism in glioblastoma, Fundação para a Ciência e a Tecnologia (PTDC/BIM­ONC/7121/20149).

Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery, Fundação para a Ciência e a Tecnologia (PTDC/QEQ-MED/7042/2014).

Validation of risk assessment model for breast cancer based on genetic polymorphisms of low penetrance, Fundação para a Ciência e a Tecnologia (PTDC/DTP-PIC/4743/2014)

microRESPIRA - Microbial community in houses from patients with chronic respiratory diseases in Estarreja. Project financed by Labex DRIIHM (PIA), via OHMI Estarreja - International Observatory Hommes-Millieux, tool of CNRS/INEE - National Center for Scientific Research/Institute of Ecology and Environment, France.

Labex DRIIHM (PIA TesseRESPIRA - A comparative study of environmental risk factors for the progression of pulmonary diseases between Tessekéré (Senegal) and Estarreja (Portugal). Project financed by), ROHM - International Observatory Hommes-Millieux, tool of CNRS/INEE - National Center for Scientific Research/Institute of Ecology and Environment, France.

Testing in vivo, the dopaminergic neuroprotective effect of GenKyoTex modulators of NADPH oxidase activity in animal models of Parkinson Disease, Genkyotex, SA

Analysis of germline mutations in the AIP and MEN1 genes in young patients with isolated pituitary macroadenomas, Portuguese Society for Endocrinology, Diabetes and Metabolism / Novartis Oncology.

Arcobacter butzleri antibiotic resistance – a genetic focus, Instituto Nacional de Saúde Dr Ricardo Jorge.
Cell-based therapy for vascular and neurological repair in stroke, Portuguese Stroke society.
Effect of Endocrine Disruptors in Spermatogonial Stem Cells: where does the protective role of Regucalcin fit in?, Prémio Professor Alexandre Moreira Investigação em Andrologia, Medicina Sexual e Reprodução, Portuguese Society of Andrology

Growth Hormone Receptor Gene Polymorphism and the Responsiveness to Recombinant Growth Hormone Therapy in the Portuguese Population, Pfizer, ref: WI216223.

Iodine deficiency in pregnancy: effects on childs cognitive development, Portuguese Society for Endocrinology, Diabetes and Metabolism / Bolsa Maria da Conceição Barbas.

Type 1 diabetes and vitamin D: a genetic association study, Portuguese Society for Endocrinology, Diabetes and Metabolism.


UID/Multi/00709/2013: Core funding CICS-UBI

Patents

Ângelo Luís, Carla Cruz, Ana Paula Duarte, Fernanda Domingues – “Isolamento e identificação de um novo derivado do resorcinol, com atividade antimicrobiana, a partir dos frutos da planta Hakea sericeaSchrader”, Patente de Invenção Nacional N.º 107033 (PT), Boletim da Propriedade Industrial (N.º 1/2015) em 2 de Janeiro de 2015, nos termos do artigo 66.º do Código da Propriedade Industrial.

C. Cruz, E. Cairrao, S. Silvestre, L. Breitenfeld, P. Almeida, J.A. Queiroz, "Método para a marcação da mitocôndria e do retículo endoplasmático utilizando compostos macrocíclicos fluorescentes”, National patent n.º 105419 (Ref.ª DMP/01/2011/284288), definitively approved and published in December of 2012.

F. Pires, F. Marques, S. Almeida, F. C. Domingues, O. Domínguez-Renedo, M. A. Alonso-Lomillo, M.J. Arcos-Martínez, A. C. Dias-Cabral. “Dispositivo electródico para deteção de glicoproteína B, procedimento de fabrico e uso dos ditos dispositivos”. National invention patent nº 107029. Published in Boletim de Propriedade Industrial nº 248/2014 edited on 2014.12.29. Patent granted 2015.07.08.

Thesis and Dissertations

Thesis and Dissertations repository of the Beira Interior University (uBibliorum):

Ficheiro com o nome: uBibliorum
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CICS-UBI - Centro de Investigação em Ciências da Saúde
[Health Sciences Research Center]
Faculdade de Ciências da Saúde
Av. Infante D. Henrique | 6201-506 Covilhã | Portugal

Tel.: 275 329 002/3 — Fax: 275 329 099
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Email: cics@fcsaude.ubi.pt
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