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Neurobiology

Neurobiology

Code	12584
Year	1
Semester	S2
ECTS Credits	6
Workload	TP(60H)
Scientific area	Biomedical Sciences
Entry requirements	None
Mode of delivery	Face-to-face
Work placements	Not applicable
Learning outcomes	To provide knowledge about: Function of the constituent cells of the nervous system and on the mechanisms of neuronal communication. Experimental methods used in neurosciences. Provide basic concepts about neuroanatomy and about the plasticity of the nervous system. Concepts: To know the cellular constitution of the nervous tissue and the forms of communication between the cells that constitute the nervous system. Integrate knowledge about the basic mechanisms of functioning of the nervous system. To relate the alterations associated to some pathologies of the nervous system with the basic neuronal mechanisms. Skills: Understand the fundamentals of different laboratory techniques and be able to develop an experimental protocol. Know how to analyze a scientific article. Know how to synthesize information and transmit it clearly and accurately to colleagues. Know how to structure information in the form of a scientific article.
Syllabus	1. Neurogenesis 2. Biology of neuronal cells 3. Synaptic transmission. Axonal transport 4. Neuronal metabolism 5. Microglia and neuroinflammation 6. Mechanisms of neurotransmission: types of neurotransmitters; synthesis and storage; axonal transport, characteristics of the release and termination of the action. 7. Dopamine 8. Serotonin 9. Acetylcholine 10. Neuropeptides 11. Glutamate, Aspartate, GABA and Glycine 12. Purines and Endocannabinoids Practical activities: Development of experimental protocols with models used in neurosciences.
Main Bibliography	Required reading: Neuroscience. Dale Purves, George J. Augustine, David Fitzpatrick , William C. Hall, Anthony-Samuel Lamantia, James O. McNamara , S. Mark Williams. Sinauer Associates; 5rd edition (2012). Neurobiology: Molecules, Cells and Systems. Gary G. Matthews. Blackwell Publishers; 2nd edition (2001). Basic Neurochemistry, 8th Edition : Molecular, Cellular and Medical Aspects. George J. Siegel, R. Wayne Albers, Scott Brady, Donald L. Price. Academic Press; edition (2011).
Language	Portuguese. Tutorial support is available in English.