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  4. Toxicology


Code 13665
Year 4
Semester A1
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Ciências Farmacêuticas
Entry requirements knowledge of analytical methods and pharmacology
Mode of delivery - THEORETICAL CLASSES Magistral and tutorial classes (assistance is mandatory, and a maximum of 15% nonattendance is allowed), following the program defined in accordance with the objectives. - LABORATORIAL CLASSES Tutorial classes, conducted by a professor (assistance is mandatory), to revise in depth some of the themes learned in the magistral classes, using an experimental approach.
Work placements Not applicable
Learning outcomes . Basic knowledge on Toxicology, and on the main factors influencing toxicity.
. To understand the importance of drug interactions and their effect on the toxic phenomenon.
. To know the basic techniques used in Toxicology and their applications.

At the end of the curricular unit the student should be able to:
Have an adequate understanding of toxicological concepts; Describe adequately the stages of the toxic process; Understand the biotransformation processes in the living being; Evaluate the toxic effects and perform the most adequate tests; Know the mechanisms of drug interactions and their toxic effects; Use the methods and techniques needed for the toxicological research, particularly in what concerns basic and analytical aspects; Know and use general tools of the scientific approach and use basic toxicology-related sources of information.
Syllabus Theoretical Program (modules)
Introduction to toxicology
Forensic toxicology, biological samples and analytical techniques applied to toxicology
Disposition, biotransformation and toxicity of toxic and potentially toxic metals
Disposition, biotransformation and toxicity of solvents and vapours
Disposition, biotransformation and toxicity of pesticides
Disposition, biotransformation and toxicity of drugs
Disposition, biotransformation and toxicity of drugs of abuse
Analytical toxicology- validation of procedures
Drug facilitated sexual assault

Laboratory program
-P1: determination of therapeutic drugs by spectroscopy uv/vis.
-P2: determination of heavy metals by atomic absorption spectroscopy.
-P3: determination of adulterants in drugs of abuse.
-P4: detection of toxic substances in the context of clinical and forensic toxicology: case study.
-P5: determination of xenobiotics by gas chromatography/tandem mass spectrometry.
-P6: determination of paraquat in wastewater.

Main Bibliography Klaassen CD, Amdur MO, Doull J.Casarett & Doull's Toxicology: The Basic Science of Poisons. 9thEd, New York, McGraw-Hill, 2019. Clarke EGC.Clarke’s Isolation and Identification of drugs. 4thEd, London, Pharmaceutical Press, 2011. Hayes AW.Principles and methods of toxicology. 6ª Ed, Philadelphia, CRC Press, 2014. Baselt RC.Disposition of Toxic Drugs & Chemicals in Man. 12thEd, Foster City, CA, Biomedical Publications, 2020. Ellenhorn MJ.Ellenhorn’s Medical Toxicology: Diagnosis and Treatment of human poisoning. 2ªnd, Baltimore, Willians & Wilkins, 1997. Gisbert Calabuig JA, Villanueva Cañadas E.Medicina legal y toxicología. 6thEd, Barcelona,Masson, 2004. Gallardo E, Queiroz JA. The role of alternative specimens in toxicological analysis.Biomed. Chromatogr. 2008;22:795-821. Jefferey GH, et al. Vogel:Análise Química Quantitativa, 6thEd, Rio de Janeiro, Guanabara-Koogan, 2002. Skoog D, et al.Fundamentals of Analytical Chemistry, 9thEd, Fort Worth, Saunders College Publishing, 2013.
Teaching Methodologies and Assessment Criteria Classification of Teaching Learning: (Factor a x 0,40) + (Factor b x 0,60)
Factor a) Practical assessment (final grade greater than or equal to 9.5 points) with a relative weight of 40% in the final classification. Final score of the practical grade (PL) =Laboratorial component: classification of the evaluation of the knowledge acquired in the practical component (60%); performance in the laboratory through posture and ease in laboratory execution (35%) and punctuality (5%). The students must have at least 9.5/20 points in order to approve. Failure to pass in practice will imply failure of the curricular unit.

Factor b) Written test with a weight of 60% (minimum mark of 9.5 points). Final mark of 9.5 or more.
This component is subdivided into three exams: Assessment UP1-UP3 (relative weight 30%); UP4-UP5 assessment (relative weight of 30%); UP6-UP9 assessment (relative weight of 40%).

Language Portuguese. Tutorial support is available in English.
Last updated on: 2022-04-14

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