Silvia Cristina da Cruz Marques Socorro @ UBI


Foto	Nome
	Silvia Cristina da Cruz Marques Socorro Professor/a Catedrático/a Vice-Reitor/a

Sector — Cargos/Funções

Vice-Reitoria para a Investigação, Inovação e Desenvolvimento — Vice-reitor/a da Vice-Reitoria para a Investigação, inovação e desenvolvimento

Gabinete de Inovação e Desenvolvimento — Responsável do Gabinete de Apoio à Investigação, Inovação e Desenvolvimento

Departamento de Ciências Médicas — Docente do Departamento de Ciências Médicas

CICS - Centro de Investigação em Ciências da Saúde — Investigador/a

Diretor/a do(s) curso(s)

Candidatura a Financiamento: Ferramentas para Investigadores — Departamento de Ciências Médicas

Escrita Científica: Aspetos Práticos e "Hands-on" — Departamento de Ciências Médicas

Gestão de Projetos para Investigadores — Departamento de Ciências Médicas

Unidades Curriculares

Publicações Científicas Mais Recentes

(Informação importada da plataforma CiênciaVitae)

Artigo em revista/Journal article

Sandra M. Rocha; Daniel Nascimento; Rafaella S. Coelho; Ana Margarida Cardoso; Luís A. Passarinha; Sílvia Socorro; Claúdio J. Maia. "STEAP1 Knockdown Decreases the Sensitivity of Prostate Cancer Cells to Paclitaxel, Docetaxel and Cabazitaxel". International Journal of Molecular Sciences (2023) url
Henrique J. Cardoso; Marília I. Figueira; Tiago M.A. Carvalho; Catarina D.M. Serra; Cátia V. Vaz; Patrícia A. Madureira; Sílvia Socorro. "Androgens and low density lipoprotein-cholesterol interplay in modulating prostate cancer cell fate and metabolism". Pathology - Research and Practice (2022) url
Sandra M. Rocha; Sílvia Socorro; Luís A. Passarinha; Claúdio J. Maia. "Comprehensive Landscape of STEAP Family Members Expression in Human Cancers: Unraveling the Potential Usefulness in Clinical Practice Using Integrated Bioinformatics Analysis". Data (2022) url
Henrique J. Cardoso; Marília I. Figueira; Cátia V. Vaz; Tiago M. A. Carvalho; Luís A. Brás; Patrícia A. Madureira; Paulo J. Oliveira; Vilma A. Sardão; Sílvia Socorro. "Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5a-dihydrotestosterone regulation". Cellular Oncology (2021) url
Josué Carvalho; Jéssica Lopes-Nunes; Joana Figueiredo; Tiago Santos; André Miranda; Micaela Riscado; Fani Sousa; et al. "Molecular Beacon Assay Development for Severe Acute Respiratory Syndrome Coronavirus 2 Detection". Sensors (2021) url

Capítulo de livro/Book chapter

Sara Correia; Pillai, H; Silva. Ams; Santos, Vm; Socorro, Sílvia. "The horizons of regucalcin in male reproduction.". In Regucalcin: Metabolic Regulation and Disease: Nova Science Publishers, Inc,, 2019.
Publicado
Figueira, Marília I.; Cardoso, Henrique J.; Socorro, Sílvia. "The Role of GPER Signaling in Carcinogenesis: A Focus on Prostate Cancer". In Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs, 59-117: Springer International Publishing, 2018.
Publicado
Cavaco, J.E.; Laurentino, S.; Correia, S.; Pinto, P.; Socorro, S. "Naturally occurring androgen receptor splice variants: Impact on androgen signaling pathways", 2014.
Pinto, P.; Estêvão, M.D.; Socorro, S. "Androgen receptors in non-mammalian vertebrates: Structure and function". In Androgen Receptor: Structural Biology, Genetics and Molecular Defects, 2014.
Dias, T.R.; Alves, M.G.; Neuhaus-Oliveira, A.; Socorro, S.; Silva, B.M.; Oliveira, P.F. "Implications of diabetes on sperm glucose uptake and metabolism", 2013.

Nota Biográfica

(Informação importada da plataforma CiênciaVitae)

Sílvia Socorro is Full Professor of Biomedicine at the Faculty of Health Sciences of University of Beira Interior (UBI) and the Vice-Rector for Research, Innovation and Development. Silvia Socorro has a PhD in Biological Sciences (2001) and obtained the Habilitation degree in Biomedicine in 2013. She taught several curricular units of B.Sc, M.Sc. and Ph.D. programmes, namely the Ph.D. programme in Biomedicine, being responsible for the Scientific Writing modules. Research interests cover the action of sex steroid hormones, endocrine disruptors and other metabolic regulators in the control of cell survival, energy metabolism and calcium homeostasis in male reproduction and prostate cancer. Sílvia Socorro has supervised 3 post-doctoral projects and 7 PhD theses and co-authored more than 80 articles (Scopus h-index 28) in specialized journals in the fields of cell and molecular biology, reproduction and cancer. She is a member of the Editorial Board of international indexed journals and a member of national and international scientific organizations, namely, the ASPIC (Portuguese Association for Cancer Research) and the EACR (European Association for Cancer Research).

Distinções e Prémios

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Prémio
2022	Award Professor Alexandre Moreira Investigação in Andrology, Sexual Medicine and Reproduction 2018-2019 - Sociedade Portuguesa de Andrologia, Lisboa, Lisboa, Portugal
2021	Prémio Carreira Alumni da Universidade do Algarve - Universidade do Algarve, Faro, Faro, Portugal
2018	Award Professor Alexandre Moreira Investigação in Andrology, Sexual Medicine and Reproduction 2016-2017 - Sociedade Portuguesa de Andrologia, Lisboa, Lisboa, Portugal

Projectos e Financiamentos

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Bolsa

• ARGOS - Desregulação do tecido Adiposo peRiprostático induzida por químicos ambientais e aGressividade do cancrO da próstata ARGOS (Em curso)

• MICROBIO-PCa - Estudo das alterações metabólicas do cancro da próstata desencadeadas pelo bacterioma: implicações na progressão da doença e na clínica MICROBIO-PCa (Em curso)

• Genes and sex change: steroid receptors and novel genes in seabream (Sparus aurata) BPD/7129/2001

• Cloning and characterisation of seabream (Sparus aurata) estrogen receptors. BD/9214/96

Projeto

• CICS4COVID - Testar, Rastrear, e Inovar no Diagnóstico da COVID-19 CENTRO-01-0145-FEDER-072541 (Concluído)

Publicações

Selected Publications

Carvalho TMA, Cardoso HJ, Figueira MI, Vaz CV, Socorro S (2019) The peculiarities of cancer cell metabolism: a route to metastasization and a target for therapy. Eur. J Med Chem 171: 343-363
Mateus I, Feijó M, Espínola LM, Vaz C, Correia S, Socorro S (2018) Glucose and glutamine handling in the Sertoli cells of transgenic rats overexpressing regucalcin: plasticity towards lactate production Sci Rep 8(1): 10321
Correia S, Vaz CV, Silva AM, Cavaco JE, Socorro S (2017) Regucalcin counteracts tert-butyl hydroperoxide and cadmium-induced oxidative stress in rat testis. J Appl Toxicol. 37(2):159-166.
Figueira MI, Correia S, Vaz CV, Cardoso HJ, Gomes IM, Marques R, Maia CJ, Socorro S (2016) Estrogens down-regulate the stem cell factor (SCF)/c-KIT system in rat prostate: evidence of antiproliferative and apoptotic effects Biochem Pharmacol 99:73-87.
Vaz CV, Correia S, Cardoso HJ, Figueira MI, Marques R, Maia CJ and Socorro S (2016) The emerging role of regucalcin as a tumor suppressor: facts and views Curr Mol Med 16 (7): 1-13.
Vaz CV, Marques R, Alves MG, Oliveira PF, Cavaco JE, Maia CJ, Socorro S (2016) Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes J Cancer Res Clin Oncol 142(1):5-16.
Vaz CV, Marques R, Maia CJ, Socorro S (2015) Aging-Associated Changes in Oxidative stress, Cell proliferation and Apoptosis are Prevented in the Prostate of Transgenic Rats Overexpressing Regucalcin Transl Res 166 (6): 693-705.
Vaz CV, Rodrigues DB, Socorro S, Maia CJ (2015) Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells Biochim Biophys Acta Mol Cell Res 1853(10 Pt A):2621-2628.
Correia S, Cardoso HJ, Cavaco JE, Socorro S (2015) Estrogens as apoptosis regulators in mammalian testis: angels or devils? Expert Rev Mol Med 17: e2.
Cardoso HJ, Vaz CV, Correia S, Figueira MI, Marques R, Maia CJ, Socorro S (2015) Paradoxical and contradictory effects of Imatinib in two cell line models of hormone-refractory prostate cancer. Prostate. 75(9):923-935.
Marques R, Vaz CV, Maia CJ, Gomes M, Gama A, Alves G, Santos CR, Schmitt, F, Socorro S (2015) Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis. Exp Cell Res. 330(2):325-335.
Correia S, Alves MR, Cavaco JE, Oliveira PF. Socorro S. (2014) Estrogenic regulation of testicular expression of SCF and c-kit: implications in germ cell survival and male fertility. Fertil Steril. 102(1): 299-306.
Marques R, Maia CJ, Vaz C, Correia S, Socorro S (2014) The diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to disease Cell Mol Life Sciences 71:93-111
Correia S, Guerreiro PM, Oliveira PF, Lopes G, Alves MG, Canário AVM, .E. Cavaco JE, Socorro S (2013) Sperm parameters and epididymis morphology and function in transgenic rats overexpressing the Ca²⁺-binding protein regucalcin: a hidden role for Ca²⁺ in epididymal function? Mol Hum Rep 19(9): 581-589
Vaz CV, Alves MG, Marques R, Moreira PI, Oliveira PF, Maia C, Socorro S (2012). Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile Int J Biochem Cell Biol 44 (11): 2077-2084.
Laurentino S, Correia S, Cavaco JE, Oliveira PF, Rato L, Sousa M, Barros A, Socorro S (2011) Regucalcin is broadly expressed in male reproductive tissues and a new androgen target gene in mammalian testis. Reproduction 142(3): 447-456.
Laurentino S, Cavaco JEB, Barros A, Sousa M and Socorro S. (2009) Estrogen Receptors α and β in Human Testis: both isoforms are expressed. Syst Biol Reprod Med. 55(4): 137-44.