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Renato Emanuel Felix Boto

Professor/a Associado/a

Sector — Cargos/Funções

Departamento de Química — Docente do Departamento de Química

CICS - Centro de Investigação em Ciências da Saúde — Investigador/a

Unidades Curriculares

Publicações Científicas Mais Recentes


(Informação importada da plataforma CiênciaVitae)

    Artigo em revista/Journal article

    1. Eurico Lima; Andreia G. Barroso; Margarida A. Sousa; Octávio Ferreira; Renato E. Boto; José R. Fernandes; Paulo Almeida; et al. "Picolylamine-functionalized benz[e]indole squaraine dyes: Synthetic approach, characterization and in vitro efficacy as potential anticancer phototherapeutic agents". European Journal of Medicinal Chemistry (2022) url
    2. João L. Serrano; Ana Maia; Adriana O. Santos; Eurico Lima; Lucinda V. Reis; Maria J. Nunes; Renato E. F. Boto; Samuel Silvestre; Paulo Almeida. "An Insight into Symmetrical Cyanine Dyes as Promising Selective Antiproliferative Agents in Caco-2 Colorectal Cancer Cells". Molecules (2022) url
    3. Margarida A. Sousa; Eurico Lima; Octávio Ferreira; Renato E. Boto; Paulo Almeida; Lucinda V. Reis. "In Vitro and In Silico Evaluation of Indole-Bearing Squaraine Dyes as Potential Human Serum Albumin Fluorescent Probes". Chemosensors (2022) url
    4. Vanessa S. D. Gomes; João C. C. Ferreira; Renato E. F. Boto; Paulo Almeida; Jose R. Fernandes; Maria João Sousa; M. Sameiro T. Gonçalves; Lucinda V. Reis. "Squaraine Dyes Derived from Indolenine and Benzo[ e ]indole as Potential Fluorescent Probes for HSA Detection and Antifungal Agents". Photochemistry and Photobiology (2022) url
    5. Boto, Renato. "Squaraine dyes as serum albumins probes: Synthesis, photophysical experiments and molecular docking studies". Bioorganic Chemistry (2021) url

    Capítulo de livro/Book chapter

    1. Boto, Renato. "A Free-Solvent Approach for Chalcone Synthesis via an Aldol Reaction". Reino Unido, 2017.
    2. M. L. F. M. Pacheco; S. F. P. Friães; Renato Boto; Paulo Jorge Da Silva Almeida; A. M. Silva; Lucinda V. Reis, L. V. Reis, L. Reis. "Synthesis of a Squarylium Cyanine Dye as Potential Photosensitizer for Photodynamic Therapy (PDT), 77, 342-346.". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), 301-305: Royal Society of Chemistry, 2017.
      Publicado

    Nota Biográfica


    (Informação importada da plataforma CiênciaVitae)
    Renato Emanuel Félix Boto is graduated in Chemistry - Analytical Chemistry (1993) by University of Aveiro, finished the Proofs similar to MSc "Provas de Aptidão Pedagógica e Capacidade Científica" (1999) by University of Beira Interior and completed his PhD in Chemistry (2007) by the same University. His PhD thesis is entitled "Synthesis and Characterization of Carboxycarbocyanines and their Application as Ligands in Dye-Affinity Chromatography for Protein Purification". From November 1994 started his academic and research activities in the Chemistry Department of University of Beira Interior as Intern Assistant (1994-1999), as Assistant (1999-2007) and as Assistant Professor since 2007. From 2008 became an integrated member of Health Sciences Research Centre of University of Beira Interior (CICS - UBI) and now is member and vice-coordinator of the BB - Biopharmaceuticals and Biomaterials Research Group. Since 2015 is the Course Coordinator of the first Cycle in Biochemistry in University of Beira Interior. Renato Boto co-authored 30 articles in international peer reviewed journals, 2 book chapters, has 259 citations by 159 documents, 53 collaborator co-authorship of scientific papers and authored/co-authored of several communications at scientific meetings (national and international). Renato Boto participated as a team member in 5 research projects. The pedagogical capacity of Renato Boto is supported by recurrent teaching activities of mainly Organic Chemistry at University of Beira Interior, Portugal. Renato Boto completed the supervision of 6 MSc dissertations and co-supervised 3. The pedagogical capacity of Renato Boto is supported by recurrent teaching activities, mainly in Organic Chemistry at University of Beira Interior, Portugal. His scientific research is mainly focus on the synthesis/organic chemistry and medicinal chemistry areas, with a special interest in the development of new cyanine dyes with biological properties. He is also interested in applying these dyes as photosensitizers for photodynamic cancer therapy, as fluorescent probes for proteins detection and as ligands in chromatographic supports to be used in DNA and protein separation.

    Projectos e Financiamentos


    (Informação importada da plataforma CiênciaVitae)

    Projeto

    • C4 - Centro de Competências em Cloud Computing / C4 Cloud Computing Competences Centre CENTRO-45-2018-10 (Em curso)
    • ICON-Interdisciplinary Challenges On Neurodegeneration CENTRO-01-0145-FEDER-000013 (Concluído)
    • Affinity Interactions between Cyanine Dyes and Biomolecules in Chromatographic Processes Provided by PTCRIS: 100896 (Concluído)
    • Development of New Supports for Dye-Affinity Chromatography POCTI/2002/QUI/44776 (Concluído)
    • New Cyanine Photosensitizers for Photodynamic Therapy of Cancer POCTI/QUI/32915/1999 (Concluído)

    Mais Info

    Interesses de investigação

    Domínio de especialização:

    • Química Orgânica

    Actuais interesses de investigação:

    • Síntese de corantes funcionais da família das cianinas e de derivados de aminoácidos, com grupos potencialmente reactivos por forma a serem imobilizados nas matrizes cromatográficas típicas, tais como celulose e agarose, bem como grupos substituintes que potenciem o bio-reconhecimento por parte de proteínas.
    • Desenvolvimento de métodos de imobilização de corantes a matrizes cromatográficas. Avaliação dos suportes sintetizados por cromatografia de afinidade na separação de proteinas.

    Publicações

    Publicações mais relevantes:

     

    1. Friães, A. M. Silva, R. E. Boto, D. Ferreira, J. R. Fernandes, E. B. Souto, P. Almeida , L. F. V. Ferreira , L. V. Reis, “Synthesis, Spectroscopic Characterization and Biological Evaluation of Unsymmetrical Aminosquarylium Cyanine Dyes”, Bioorganic & Medicinal Chemistry 2017, 25, 3803–3814. DOI: 10.1016/j.bmc.2017.05.022
    1. D. Martins, M. L. Pacheco, R. E. Boto, P. Almeida, J. P. S. Farinha, L. V. Reis, ” Synthesis, characterization and protein-association of dicyanomethylene squaraine dyes”, Dyes and Pigments 2017, 147, 120-129. DOI: 10.1016/j.dyepig.2017.07.070
    1. Santos, A. Brito, R. Boto, P. Sousa, P. Almeida, C. Cruz, C. Tomaz, “Influenza DNA vaccine purification using pHEMA cryogel support”, Separation and Purification Technology 2018, 206, 192-198. DOI: 10.1016/j.seppur.2018.06.002
    1. Lima, O. Ferreira, V. S. D. Gomes, A. Santos, R. Boto, J. R. A. Fernandes, P. Almeida, S. Silvestre, L V. Reis, “Synthesis and in vitro evaluation of the antitumoral phototherapeutic potential of squaraine cyanine dyes derived from indolenine”, Dyes and Pigments 2019, 167, 98-108. DOI: 10.1016/j.dyepig.2019.04.007
    1. Friães, E. Lima, R. E. Boto, D. Ferreira, J. R. Fernandes, F. V. Ferreira, A. M. Silva, L. V. Reis. “Photophysicochemical properties and in vitro phototherapeutic effects of iodoquinoline- and benzothiazole-derived unsymmetrical squaraine cyanine dyes” Applied Sciences (Switzerland) 2019, 9(24) 5414. DOI:10.3390/app9245414
    1. L. Serrano, P. F. Soeiro, M. A. Reis, R. E. F. Boto, S. Silvestre, P. Almeida, “Synthesis and process optimization of symmetric and asymmetric barbiturates C5-coupled with 2,1-benzisoxazoles”, Molecular Diversity 2020, 24, 155-166. DOI:10.1007/s11030-019-09937-4
    1. Lima, O. Ferreira, J. F. Silva, A. Santos, R. Boto, J. R. A. Fernandes, P. Almeida, S. Silvestre, L. V. Reis, “Photodynamic activity of indolenine-based aminosquaraine cyanine dyes: Synthesis and in vitro photobiological evaluation”, Dyes and Pigments 2020, 174, 108024. DOI:10.1016/j.dyepig.2019.108024
    1. F. Soeiro, J. L. Serrano, J. A. Paixão, R. E. F. Boto, S. Silvestre, P. Almeida, “The Synthesis of 2-Spiroindolin-3-one-(thio)barbiturates from 2,1-Benzisoxazoles. A Rearrangement Promoted by Thermal Conditions”, Synthesis, 2020, 52(14): 2065-2072. DOI: 10.1055/s-0039-1690865
    1. Tiago D. Martins, Eurico Lima, Renato E. Boto, Diana Ferreira, José
      Fernandes, Paulo Almeida, Luis F. V. Ferreira, Amélia M. Silva, Lucinda
      V. Reis “Red and near-infrared absorbing dicyanomethylene squaraine cyanine
      dyes: photophysicochemical properties and antitumor photosensitizing effects” Materials 2020, 13, 2083. DOI: 10.3390/ma13092083 
    1. Tânia C. D. Fernandes; Eurico Lima; Renato E. Boto; Diana Diana Ferreira; José R. Fernandes; Paulo Almeida; Luis F. V. Ferreira; Amélia M. Silva; Lucinda Vaz dos Reis ”In vitro   phototherapeutic effects of indolenine-based mono- and dithiosquaraine cyanine dyes against Caco-2 and HepG2 human cancer cell lines” Photodiagn Photodyn, 2020, 31, 101844. DOI: 1016/j.pdpdt.2020.101844
    1. Eurico Lima, Renato E. Boto, Diana Ferreira, José R. Fernandes,
      Paulo Almeida, Luis F. V. Ferreira, Eliana B. Souto, Amélia M. Silva,
      Lucinda V. Reis “Quinoline- and benzoselenazole-derived unsymmetrical squaraine cyanine dyes: design, synthesis, photophysicochemical features and light-triggerable antiproliferative effects against breast cancer cell lines”, Materials 2020, 13(11), 2646. DOI: 10.3390/ma13112646
    1. Vanessa S. D. Gomes, Helena M.R. Gonçalves, Renato E. F. Boto, Paulo Almeida, Lucinda V. Reis, “Barbiturate squaraine cyanine dyes as fluorescent probes for serum albumins detection” J Photoch Photobio A, 2020, 400, 112710. DOI: 1016/j.jphotochem.2020.112710

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