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Silvia Cristina da Cruz Marques Socorro

Professor/a Catedrático/a

Sector — Cargos/Funções

Departamento de Ciências Médicas Docente do Departamento de Ciências Médicas

CICS - Centro de Investigação em Ciências da Saúde Investigador/a


Sílvia Socorro (Socorro S) has a PhD in Biological Sciences (2001) and has joined the University of Beira Interior (UBI) in 2002 as Assistant Professor.
In 2013 has received the Habilitation degree in Biomedicine by UBI.
Actually, is Associate Professor with Habilitation and the Coordinator of the CICS-UBI research group “Hormones and Inflammation in Health and Disease”. Sílvia Socorro leads a research group studying the endocrinology, metabolism and carcinogenesis of reproductive tissues.

Diretor/a do(s) curso(s)

Mais Info

Research interests target the action of sex steroids in reproduction and cancer. Sex hormones regulate male and female reproductive biology, and also play a role in the carcinogenesis of reproductive tissues. In the last years, the physiological actions of estrogens/androgens, and the identification of steroid-responsive genes in reproductive tissues has deserved special attention. Novel proteins with a role in the control of cell survival and death, and with impact both on male fertility and cancer were identified. Research work also implicated estrogens/ androgens in the control of cell metabolism. It was shown that androgens regulate the glycolytic metabolism of testicular and prostate cancer cells and that this regulation is associated with the progression of disease. Current research is focused on the exploitation of the metabolic alterations associated with male infertility and cancer, and on the development of steroid- and metabolism-based biomarkers and therapeutic options.


Selected Publications

Silva AMS, Correia S, Casalta-Lopes JE, Mamede AC, Cavaco JEB, Botelho MF, Socorro S#, Maia CJ.# The protective effect of regucalcin against radiation-induced damage in testicular cells Life Sciences 164: 31-41.

Silva AMS, Correia S, Socorro S# and Maia CJ# (2016) Endogenous factors in the recovery of reproductive function after testicular injury and cancer Curr Mol Med 16 (1): 1-19.

Vaz CV, Correia S, Cardoso HJ, Figueira MI, Marques R, Maia CJ and Socorro S (2016) The emerging role of regucalcin as a tumor suppressor: facts and views Curr Mol Med 16 (7): 1-13.

Correia S, Vaz CV, Silva AMS, Cavaco JE and Socorro S Regucalcin Counteracts Tert-butyl Hydroperoxide and Cadmium-induced Oxidative Stress in Rat Testis. J Appl Toxicol doi: 10.1002/jat.3333.

Figueira MI, Correia S, Vaz CV, Cardoso HJ, Gomes IM, Marques R, Maia CJ, Socorro S (2016) Estrogens down-regulate the stem cell factor (SCF)/c-KIT system in rat prostate: evidence of antiproliferative and apoptotic effects Biochem Pharmacol 99:73-87.

Vaz CV, Marques R, Cardoso HJ, Maia CJ, Socorro S (2016) Suppressed glycolytic metabolism in the prostate of transgenic rats overexpressing calcium-binding protein regucalcin underpins reduced cell proliferation Transgenic Res 25(2), 139-148.

Vaz CV, Marques R, Alves MG, Oliveira PF, Cavaco JE, Maia CJ, Socorro S (2016) Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes J Cancer Res Clin Oncol 142(1):5-16.

Vaz CV, Marques R, Maia CJ, Socorro S (2015) Aging-Associated Changes in Oxidative stress, Cell proliferation and Apoptosis are Prevented in the Prostate of Transgenic Rats Overexpressing Regucalcin Transl Res 166 (6): 693-705.

Marques R, Peres CV, Vaz CV, Gomes IM, Figueira MI, Cairrão E, Verde I, Maia CJ, Socorro S (2015) 5-dihydrotestosterone regulates the expression of L-type calcium channels and calcium-binding protein regucalcin in human breast cancer cells with suppression of cell growth Med Oncol 32(9):228

Vaz CV, Rodrigues DB, Socorro S, Maia CJ (2015) Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells Biochim Biophys Acta Mol Cell Res 1853(10 Pt A):2621-2628.

Correia S, Cardoso HJ, Cavaco JE, Socorro S (2015) Estrogens as apoptosis regulators in mammalian testis: angels or devils? Expert Rev Mol Med 17: e2.

Cardoso HJ, Vaz CV, Correia S, Figueira MI, Marques R, Maia CJ, Socorro S (2015) Paradoxical and contradictory effects of Imatinib in two cell line models of hormone-refractory prostate cancer. Prostate. 75(9):923-935.

Marques R, Vaz CV, Maia CJ, Gomes M, Gama A, Alves G, Santos CR, Schmitt, F, Socorro S (2015) Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis. Exp Cell Res. 330(2):325-335.

Cardoso HJ, Figueira MI, Correia S, Vaz CV and Socorro S (2014) The SCF/c-KIT system in the male: survival strategies in fertility and cancer. Mol Reprod Dev 10.1002/mrd.22430

Figueira MI, Cardoso HJ, Correia S, Maia CJ, Socorro S (2014) Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility? Prog Histochem Cyto 10.1016/j.proghi.2014.09.001

Vaz C, Maia CJ, Marques R, Gomes IM, Correia S, Alves MG, Cavaco JE, Oliveira PF, Socorro S (2014) Regucalcin is an androgen-target gene in the rat prostate modulating cell-cycle and apoptotic pathways. Prostate. 74 (12):1189-1198.

Correia S, Alves MR, Cavaco JE, Oliveira PF. Socorro S. (2014) Estrogenic regulation of testicular expression of SCF and c-kit: implications in germ cell survival and male fertility. Fertil Steril. 102(1): 299-306.

Correia S, Alves MG, Oliveira PF, Alves MR, van Pelt AMM, Cavaco JE, Socorro S. (2014) Transgenic overexprssion of regucalcin leads to suppression of thapsigargin- and actinomycin D-induced apoptosis in the testis by modulation of apoptotic pathways. Andrology 2(2):290-298.

Marques R, Maia CJ, Vaz C, Correia S, Socorro S (2014) The diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to disease Cell Mol Life Sciences 71:93-111

Correia S, Guerreiro PM, Oliveira PF, Lopes G, Alves MG, Canário AVM, .E. Cavaco JE, Socorro S (2013) Sperm parameters and epididymis morphology and function in transgenic rats overexpressing the Ca2+-binding protein regucalcin: a hidden role for Ca2+ in epididymal function? Mol Hum Rep 19(9): 581-589

Laurentino SS, Pinto P, Tomás J, Cavaco JE, Sousa M, Barros A, Power DM, Canário AVM, Socorro S. (2013). Identification of androgen receptor variants in testis from humans and other vertebrates. Andrologia 45(3):187-94

Vaz CV, Alves MG, Marques R, Moreira PI, Oliveira PF, Maia C, Socorro S (2012). Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile Int J Biochem Cell Biol 44 (11): 2077-2084.

Laurentino S, Correia S, Cavaco JE, Oliveira PF, Rato L, Sousa M, Barros A, Socorro S (2011) Regucalcin is broadly expressed in male reproductive tissues and a new androgen target gene in mammalian testis. Reproduction 142(3): 447-456.

Laurentino S, Gonçalves, J, Cavaco JEB, Oliveira PF, Alves M, Sousa, Barros A, Socorro, S (2011) Apoptosis-inhibitor Aven is down-regulated in defective spermatogenesis and a novel estrogen target gene in mammalian testis. Fert Ster. 96 (3):745-50.

Laurentino S, Cavaco JEB, Barros A, Sousa M and Socorro S. (2009) Estrogen Receptors α and β in Human Testis: both isoforms are expressed. Syst Biol Reprod Med. 55(4): 137-44.

Maia CJ, Santos CR, Schmitt F. and Socorro S. (2009) Regucalcin is under-expressed in human breast and prostate cancers: effect of sex steroid hormones. J. Cell. Biochem. 107(4): 667-676.


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