Sílvia Socorro leads a research group studying the endocrinology, metabolism and carcinogenesis of reproductive tissues. Research interests mainly target the action of sex steroids in reproduction and cancer. Sex hormones regulate male and female reproductive biology, also playing an important role in cancer of reproductive tissues. In the last years, the physiological actions of estrogens/androgens, and the identification of steroid-responsive genes in reproductive tissues has deserved special attention. Novel proteins with a role in the control of cell survival and death, and with impact both on male fertility and cancer have been identified. Research work also implicated estrogens/ androgens in the control of cell metabolism. Current research is focused on the exploitation of the metabolic alterations associated with male infertility and cancer, and on the development of steroid- and metabolism-based biomarkers and therapeutic options.