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Cândida Ascensão Teixeira Tomaz

Professor/a Associado/a

Sector — Cargos/Funções

Departamento de Química — Docente do Departamento de Química

CICS - Centro de Investigação em Ciências da Saúde — Investigador/a

Diretor/a do(s) curso(s)
Bioquímica — Departamento de Química

Unidades Curriculares

Publicações Científicas Mais Recentes


(Informação importada da plataforma CiênciaVitae)

    Artigo em conferência/Conference paper

    1. Mesquita, Joana; Castro de Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luis; Tomaz, Candida. "Quantitative research of VEGF-A, VEGF-B and PIGF in vitreous and serum in angiogenic ocular disorders". 2018.
      Publicado
    2. Mesquita, Joana; Castro e Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luis; Tomaz, Candida. "Quantitative analysis and correlation of VEGF-A and VEGF-B in serum and vitreous humor of patients with proliferative vs non-proliferative ocular disease". 2017.
      Publicado
    3. Mesquita, Joana; Castro Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Tavares-Ratado, Paulo; Passarinha, Luis; Tomaz, Candida. "Correlation between concentration of vitreous angiogenic cytokines (VEGF-B and PIGF) with central retinal thickness and macular volume in diabetic retinopathy patients". 2016.
      Publicado
    4. Mesquita, Joana; Castro Sousa, Joao Paulo; Tavares-Ratado, Paulo; Vaz-Pereira, Sara; Neves, Arminda; Rocha, Ana S.; Santos, Fatima; Passarinha, Luis; Tomaz, Candida. "Comparison of serum and vitreous PIGF in diabetic retinopathy patients and nondiabetic patients". 2015.
    5. Bicho, D.; Caramlo-Nunes, C.; Santos, B. F.; Sousa, A.; Sousa, F.; Queiroz, J. A.; Tomaz, C. T.. "Amino acid derivatized monoliths for purification of a DNA vaccine against influenza". 2015.
      Publicado

    Artigo em revista/Journal article

    1. David Moreira; Jéssica Lopes-Nunes; Fátima Milhano Santos; Maria Paula Cabral Campello; Maria Cristina Oliveira; António Paulo; Cândida Tomaz; Carla Cruz. "Assessment of Aptamer as a Potential Drug Targeted Delivery for Retinal Angiogenesis Inhibition". Pharmaceuticals (2023) url
    2. Martins, Sílvia; António, Natália; Carvalheiro, Tiago; Laranjeira, Paula; Rodrigues, Ricardo; Gonçalves, Lino; Tomaz, Cândida; Paiva, Artur. "Reduced numbers of regulatory T cells in chronic heart failure seems not to be restored by cardiac resynchronization therapy". BMC Cardiovascular Disorders (2023) url
    3. Santos, Fátima M.; Ciordia, Sergio; Mesquita, Joana; Cruz, Carla; Sousa, João Paulo Castro e; Passarinha, LuísA.; Tomaz, Cândida T.; Paradela, Alberto. "Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases". Frontiers in Immunology (2023) url
    4. dos Santos, Fátima Milhano; Ciordia, Sergio; Mesquita, Joana; de Sousa, João Paulo Castro; Paradela, Alberto; Tomaz, Cândida Teixeira; Passarinha, LuísAntónio Paulino. "Vitreous humor proteome: unraveling the molecular mechanisms underlying proliferative and neovascular vitreoretinal diseases". Cellular and Molecular Life Sciences (2022) url
    5. Moreira, David; Leitão, Daniela; Lopes-Nunes, Jéssica; Santos, Tiago; Figueiredo, Joana; Miranda, André; Alexandre, Daniela; et al. "G-Quadruplex Aptamer-Ligand Characterization". Molecules (2022) url

    Capítulo de livro/Book chapter

    1. Tomaz, Cândida T. "Hydrophobic interaction chromatography *". In Liquid Chromatography: Fundamentals and Instrumentation, Handbooks in Separation Science, 171-190: Elsevier, 2017.
      Publicado
    2. Caramelo-Nunes, Catarina; Tomaz, Cândida T. "Specific Recognition of Supercoiled Plasmid DNA by Affinity Chromatography Using a Synthetic Aromatic Ligand". In Methods in Molecular Biology: Affinity Chromatography Methods and Protocols editado por Senta Reichelt, 47-54: Springer New York, 2015.
      Publicado
    3. C. Peixinho, P Tavares-Ratado, M. Gabriel, A. Romeira, C. Lozoya-Ibanez, L. Taborda-Barata, C.T. Tomaz, C. "Different in vivo reactivity profile in health care workers and patients with spina bifida to internal and external latex glove surface-derived allergen extracts". In World Biomedical Frontiers , Allergy: BENTHAM SCIENCE PUBLISHERS, 2013.
    4. Tomaz, C.T.; Queiroz, J.A. "Hydrophobic Interaction Chromatography". In Liquid Chromatography: Fundamentals and Instrumentation. editado por S. Fanali, P. Haddad, D. K. Lloyd, C.F. Poole, P.J, 121-141: Elsevier, 2013.
      Publicado
    5. Silva, N.; Prudencio, C.; Tomaz, C.; Fernandes, R. "Antimicrobial susceptibility in clinical isolates of Staphylococcus aureus harbouring of mecA and lukFS-PV genes in Northern Portugal". In Science and Technology Against Microbial Pathogens: Research, Development and Evaluation editado por A Mendez-Vilas, 275-280: World Scientific Publishing Co. Pte. Ltd, 2011.

    Nota Biográfica


    (Informação importada da plataforma CiênciaVitae)
    Cândida Tomaz graduated in Pharmaceutical Sciences (1990) by University of Coimbra, Portugal, and completed her PhD in Biochemistry (2002) at University of Beira Interior (UBI)In 1990, she started her academic activities as Junior Teaching Assistant and since 2011 is Associate Professor in Chemistry Department of the Faculty of Sciences at UBI. She was Course Director of the 1st and 2nd Cycles in Biochemistry and at present she is the Coordinator of the Biochemistry Doctoral Program in UBI. C Tomaz completed the supervision almost 50 MSc and 7 PhD theses and at present is supervising or co-supervising 3 PhD and 1 MSc dissertationThroughout his academic career C Tomaz has held several positions at UBI, namely member of the General Council of the University, President of Sciences Faculty Council, President of Sciences Faculty Pedagogical Council and member of Coordinator Institute of Research of UBI. She was also Vice-coordinator of Biopharmaceutical and Biomaterials Research Group and Executive Board member of Health Sciences Research Centre (CICS- UBI)C Tomaz published almost 60 papers in international peer reviewed journals, 8 book chapters and has about 1200 citations. She has published in specialized and multidisciplinary high impact scientific journals and is also member of editorial reviewer boards. She collaborated with international institutions, namely, Antwerp University Hospital, Lascaray Research Centre, University of the Basque Country, National Biotechnology Center (CSIC) at Madrid and also with several national institutions namely, Univ. Coimbra, Univ. Minho, Coimbra Institute for Clinical and Biomedical Research, and several hospitals (CHUCB, HUC, ULS Guarda, CH Leiria). C Tomaz participated in 21 research projects, mostly in the Health Biotechnology field, and she was the principal investigator in 6 projects, 2 of them funded by Novartis Farma and 1 awarded by Ordem dos FarmacêuticosShe has been working since many years in downstream processing for the purification of biopharmaceuticals, with particular focus on the development of new chromatographic supports, such as monoliths and cryogels. Currently she is working in a project for development of innovative strategies for treatment of ocular neovascular diseases.

    Distinções e Prémios


    (Informação importada da plataforma CiênciaVitae)
    Prémio
    2021BInov 2021 Award, Innovation Scholarship - Order of Pharmacists, Lisbon, Lisbon, Portugal
    2019Best Poster Presentation - XX EuroFoodChem Conference, Porto, Porto, Portugal
    2014Best Poster Presentation - European Academy of Allergy and Clinical Immunology, Zurich, Suiça
    2013Best Scientific Abstract - European Academy of Allergy and Clinical Immunology, Zurich, Suiça
    2012Best Oral Communication - Portuguese Society of Medical Hydrology, Monchique, Monchique, Portugal
    Outra distinção
    2011Best Poster
    2010Best Poster

    Prémios Recebidos

    Projectos e Financiamentos


    (Informação importada da plataforma CiênciaVitae)

    Bolsa

    • CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIsease: wheN two are bettEr than one BINOV 2021 (Concluído)
    • Proteomic and Metabolomic Analysis of Vitreous Humor in Vitreoretinal Diseases Ref.14- C4 Cloud Computing (Concluído)

    Projeto

    • Vaginal gel for topical application in precancerous lesions caused by the HPV CENTRO-45-2021-30 (Em curso)
    • CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIseases UIDP/Multi/00709/2020 (Concluído)
    • CheckImmune Project 251_596879301 (Em curso)

    Mais Info

    Principais áreas de interesse científico:

    • Biotecnologia: Produção e Purificação de Biomoléculas /Processos cromatográficos (Cromatografia de Interacção hidrofóbica, Cromatografia de afinidade)
    • Bioquímica Clínica/ Autoimunidade/ Imunologia

    Publicações

    Publicações mais relevantes:

    • C.T. Tomaz e J.A. Queiroz, “Studies on Chromatographic Fractionation of Trichoderma reesei Cellulases by Hydrophobic Interaction Chromatography”, Journal of Chromatography. A, 865, 123-128, 1999.
    • J.A. Queiroz, C.T. Tomaz e J..M.S. Cabral “Hydrophobic Interaction Chromatography of Proteins”, Journal of Biotechnology, 87, 143-159, 2001.
    • C.T. Tomaz, D. Duarte e J.A. Queiroz, “Comparative Study for Cellulases Fractionation on Some Hydrophobic Interaction Chromatography Adsorbents”, Journal of Chromatography A, 944, 211-216, 2002.
    • C.T. Tomaz, A. Rocha e J.A. Queiroz, “Hydrophobic Interaction Chromatography of Trichoderma reesei Cellulases on Polypropylene Glycol-Sepharose”, Separation Science and Technology, 37, 1641-1651, 2002.
    • C.T. Tomaz e J.A. Queiroz “Fractionation of Trichoderma reesei Cellulases by Hydrophobic Interaction Chromatography on Phenyl-Sepharose”, Biotechnology Letters, 26, 223-227, 2004.
    • F. Sousa, C. T. Tomaz, D. M. F. Prazeres, J. A. Queiroz, “Separation of supercoiled and open circular plasmid DNA isoforms by chromatography with a histidine-agarose support” Analytical Biochemistry, 343, 183-185, 2005.
    • C. Peixinho, P. Tavares-Ratado, M.R. Tomaz, L. Taborda-Barata, C.T. Tomaz "Differential Expression of Allergens on Internal and External Surfaces of Latex Surgical Gloves: a Key to Explain Sensitization Routes in Different Risk Groups" Allergol. Immunopathol., 34 (5), 206-211, 2006.
    • C. Peixinho, P. Tavares-Ratado, M.R. Tomaz, L. Taborda-Barata, C.T. Tomaz “Latex Gloves: new insights to explain different sensitization profiles in different risk groups” British Journal of Dermatology, 159 (1), 132-136, 2008.
    • P. Fonseca, P. Tavares-Ratado, C. T. Tomaz "Interference of Dermatophagoides’ specific IgG in the quantification of mite’s specific IgE" Journal of Immunoassay and Immunochemistry, 30, 338-347, 2009.
    • A. Silva, R. E. F. Boto, C. T. Tomaz, J. A. Queiroz, P. Almeida “Rhodamine B as Ligand for Affinity Chromatography. Chromatographic Studies on Derivatized Beaded Cellulose” Journal of Chromatographic Science, 48, 240-244, 2010.
    • C. Amaral, E. Gallardo, R. Rodrigues, R. Pinto Leite, D. Quelhas, C. Tomaz, M.L. Cardoso “Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects” Journal of Chromatography B (doi:10.1016/j.jchromb.2010.06.010).

    Contactos

    ctomazðubi÷pt
    275319762
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    Data da última atualização: 2024-04-19
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