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Bioinorganic Chemistry

Code 10246
Year 2
Semester S1
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Chemistry
Mode of delivery Face-to face
Work placements n/a
Learning outcomes The aims of this course is to provide the basis of Inorganic and Bioinorganic Chemistry:
- Importance of inorganic chemistry for living
- Properties of coordination compounds and organometallic compounds
- Role of metals in metallobiomolecules
The student should:
- Recognize the importance of inorganic chemistry to living beings.
- Understand fundamental redox processes that occur in living organisms.
- Be able to interpret Latimer diagrams, Frost, and Pourbaix in order to understand which species are more stable under certain conditions of pH and potential.
- Know the basic properties of coordination and organometallics compounds.
- Know and understand the role of metals in metallobiomolecules.
- Understand the importance of some coordination and organometallics compounds with therapeutic functions.
Syllabus 1. Chemistry of Oxygen. Oxides, Oxoacids and peroxyacids.
2. Chemistry of Hydrogen.
3. Essential inorganic species in living organisms. Latimer diagrams, Frost, and Pourbaix.
4. Coordination and organometallic compounds. Crystal Field Theory. Octahedral, tetrahedral, tetragonal and square complexes. Jahn-Teller effect. Energy stabilization of the crystal field. Magnetic properties of the complexes.
5. Properties of Organometallic. Stability and 18 electrons rule.
6. The coordination chemistry in biological systems: metallobiomolecules (metalloproteins and / or metalloenzymes). Metallobiomolecules with different transport functions: electron, metal and oxygen. Metalobioenzimas redox and non-redox.
7. Metal toxicity.
8. Diagnostic and therapeutic applications of pharmaceutical compounds with metals.
Practice – Laboratory work about metal properties, coordination compounds and metallobiomolecules.
Main Bibliography Fundamental

- Química Inorgânica Básica (2004) Ana M. V. Cavaleiro, Universidade de Aveiro

- S.J. Lippard & J.M. Berg (1994) - Principles of Bioinorganic Chemistry. University Science Books.

- R. Crichton, (2001) - Inorganic Chemistry of Iron Metabolism, 2nd ed. John Wiley & Sons.

- J.M. Berg, J.L. Timoczko, L. Stryer,(2005) - Biochemistry, 5 ed, W. H. Freeman

- D. E. Metzler Biochemistry The Chemical Reactions of Living Cells, 2nd ed Elsevier
Language Portuguese. Tutorial support is available in English.
Last updated on: 2012-05-21

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