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Medicinal Chemistry
Organic Chemistry

Organic Chemistry

Code	10249
Year	2
Semester	S1
ECTS Credits	6
Workload	PL(30H)/T(30H)
Scientific area	Chemistry
Mode of delivery	Face-to-face with recourse to e-learning
Learning outcomes	This course unit aims to teach the basic knowledge to classify the main types of reactions in organic chemistry and its understanding through its mechanism. At the end of the course unit the student should be able to combine the basic knowledge learned with an adequate bibliographic support, in order to predict the chemical behavior of compounds possessing the main functional groups and therefore to allow the development of his/her skills to identify, design and produce raw-materials and drugs. Should also be able to recognize the necessity to maintain a constant self-leaning based on the collection, analysis and organization of the information on pharmaceutical sciences, and to be able to communicate and discuss it in a valuable way. The student must also possess a set of experimental skills in organic chemistry.
Syllabus	1 Introduction to spectroscopy 1.1 Infrared spectroscopy 1.2 Mass spectrometry 1.3 Nuclear magnetic resonance spectroscopy 2 Reactions in organic chemistry 2.1 Main types 2.2 Reaction mechanisms and the use of curved arrows utilization to their illustration. 3 Saturated carbons 3.1 Nucleophilic substitution reactions 3.2 Elimination reactions 3.3 Radical reactions 4 Unsaturated carbons 4.1 Electrophilic addition 4.2 Conjugated systems 4.3 Alkenes formation 5 Carbonyl group 5.1 Nucleophilic addition 5.2 Conjugate addition 5.3 Substitution 6 Oxidation-reduction reactions 7 Electrophilic aromatic substitution 8 Enols and enolates: reactions and formation 9 Practical cases
Main Bibliography	1. Required reading: - T. W. G. Solomons, C. B. Fryle, Organic Chemistry, 10th Edition International Student Version, LTC John Wiley and Sons Inc., 2011. 2. Recommended reading: - M. B. Smith, J. March, March’s Advanced Organic Chemistry – Reactions, Mechanisms and Structure, 6th ed., John Wiley & Sons: New York, 2007. - R.M. Silverstein, F.X. Webster, D.J. Kiemle, Identificação Espectrométrica de Compostos Orgânicos, 7ª ed, LTC Editora, Rio de Janeiro, 2006. - A. R. Tatchell, A. J. Hannaford, P. W. G. Smith, A. R. Tatchell, Vogel´s Textbook of Practical Organic Chemistry, 5th ed., Longman Scientific & Technical: New York, 1996.
Language	Portuguese. Tutorial support is available in English.