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Biochemistry II

Code 10250
Year 2
Semester S2
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Biochemistry
Mode of delivery Face to face.
Work placements Not applicable.
Learning outcomes The unit of Biochemistry II aims to develop and apply the knowledge, attitudes and skills acquired in Biochemistry I, in understanding the biochemical meaning of metabolic strategies and its regulation. At the end of this course the student should be able to:
-Describe and to explain the bioenergetic aspects related to oxidative phosphorylation, the substrate-level phosphorylation and the metabolism of the main nutritional components of living beings;
-Identify, to describe and to interpret the metabolic pathways of carbohydrates, lipids, amino acids and nucleotides;
-Compare the role of different hormones in the energy metabolism and to interpret the mechanism of hormonal regulation;
-Explain the integration of metabolic pathways and its regulation;
-Perform experimental techniques in the field of Biochemistry and to analyze and interpret the results accurately and critically;
Syllabus 1. Metabolism and Bioenergetics. Oxidation-reduction reactions in biological systems.
2. Carbohydrate metabolism. Glycolysis. Regulation. Glycogen metabolism. Gluconeogenesis. Precursors and Regulation. Pentose phosphate pathway.
3. Citric acid cycle. Regulation.
4. Oxidative phosphorylation. Electron transport chain. Regulatory phosphorylation
5 . Lipid metabolism. ß-oxidation of fatty acids. Metabolism of ketone bodies. Synthesis of lipids. Cholesterol and lipoproteins metabolism
6. Metabolism of amino acids. Urea cycle.
7. Metabolism of nucleic acids
8. Hormonal regulation and integration of mammalian metabolism
9. Experimental
Biosecurity. Hydrolysis of compounds containing phosphate groups. Determination of activity of the enzyme lactate desidrogenase . Alcoholic fermentation of glucose. Oxygen radicals: Fenton reaction. Metabolism of amino acids: determination of the activity of alanine transaminase.
Main Bibliography 1. Required reading

-D.L. Nelson e M.M. Cox (2008) Lehninger Principles of Biochemistry, 5 ed., Worth Publishers.
- J.M. Berg, J.L. Tymoczko, L. Stryer (2006) Biochemistry. 6th ed., New York: Freeman
-A.Quintas, A.P Freire, M.J. Halpern, (2008) Bioquímica - Organização Molecular da Vida, Ed.

2. Recommended reading

-D. Voet, J.G. Voet (2004). Biochemistry. 3st ed.,New York: J. Wiley & Sons.
Language Portuguese. Tutorial support is available in English.
Last updated on: 2012-05-21

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