Code |
10255
|
Year |
3
|
Semester |
S1
|
ECTS Credits |
6
|
Workload |
PL(30H)/T(30H)
|
Scientific area |
Química Medicinal
|
Mode of delivery |
Face to face lectures
|
Work placements |
Not applicable
|
Learning outcomes |
This Course aims to provide students with a set of knowledge in the area of Biotoxicology that enable them to understand the mechanisms of toxicity, that is, how a toxicant enters an organism, how it interacts with target molecules, and how the organism deals with the insult.
At the end of this course, students should be able to: -Identify the basic concepts of Toxicology; -Explain the disposition and biotransformation of toxicants in the organism; -Discuss the Mechanisms of toxicity; -Identify toxic responses to Xenobiotics; -Apply the acquired knowledge to identify and evaluate the potential hazard posed by a particular chemical; -Accomplish analytical techniques to quantify toxics in biological samples; -Work in groups and communicate to others knowledge in Biotoxicology; -Analyze and interpret experimental results with scientific rigor and critical thinking
|
Syllabus |
1.General principles of Toxicology. 2.Disposition of toxicants: absorption, distribution and excretion. 3.Biotransformation of xenobiotics. 4.Mechanisms of toxicity. Cellular dysfunction and resultant toxicities: Toxicant-Induced Cellular Dysregulation, Toxic Alteration of Cellular Maintenance. Mechanisms of Repair. 5.Toxic responses to xenobiotics: chemical carcinogenesis, mechanisms of neurotoxicity and direct tissue lesions. 6.Laboratory classes.Toxic quantification in biological samples:Determination of salicylate in serum and urine; Determination of ethanol in blood samples; search organophosphorus pesticides in soil samples; and determination of carbon monoxide concentration in the blood. Ames test.
|
Main Bibliography |
1. Required reading Casarett & Doull’s (2008) Toxicology-The Basic Science of Poisons, 7th Edition, Mc Graw-Hill,New York Boelsterli, U.A. (2003) Mechanistic toxicology, Taylor & Francis
2. Recommended reading Timbrell, J. (2000)Principles of Biochemical Toxicology, 3rd Edition, Taylor & Francis
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Language |
Portuguese. Tutorial support is available in English.
|