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  4. Biotoxicology


Code 10255
Year 3
Semester S1
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Química Medicinal
Mode of delivery Face to face lectures
Work placements Not applicable
Learning outcomes This Course aims to provide students with a set of knowledge in the area of Biotoxicology that enable them to understand the mechanisms of toxicity, that is, how a toxicant enters an organism, how it interacts with target molecules, and how the organism deals with the insult. At the end of this course, students should be able to:
-Identify the basic concepts of Toxicology;
-Explain the disposition and biotransformation of toxicants in the organism;
-Discuss the Mechanisms of toxicity;
-Identify toxic responses to Xenobiotics;
-Apply the acquired knowledge to identify and evaluate the potential hazard posed by a particular chemical;
-Accomplish analytical techniques to quantify toxics in biological samples;
-Work in groups and communicate to others knowledge in Biotoxicology;
-Analyze and interpret experimental results with scientific rigor and critical thinking
Syllabus 1.General principles of Toxicology.
2.Disposition of toxicants: absorption, distribution and excretion.
3.Biotransformation of xenobiotics.
4.Mechanisms of toxicity. Cellular dysfunction and resultant toxicities: Toxicant-Induced Cellular Dysregulation, Toxic Alteration of Cellular Maintenance. Mechanisms of Repair.
5.Toxic responses to xenobiotics: chemical carcinogenesis, mechanisms of neurotoxicity and direct tissue lesions.
6.Laboratory classes.Toxic quantification in biological samples:Determination of salicylate in serum and urine; Determination of ethanol in blood samples; search organophosphorus pesticides in soil samples; and determination of carbon monoxide concentration in the blood. Ames test.
Main Bibliography 1. Required reading
Casarett & Doull’s (2008) Toxicology-The Basic Science of Poisons, 7th Edition, Mc Graw-Hill,New York
Boelsterli, U.A. (2003) Mechanistic toxicology, Taylor & Francis

2. Recommended reading
Timbrell, J. (2000)Principles of Biochemical Toxicology, 3rd Edition, Taylor & Francis

Language Portuguese. Tutorial support is available in English.
Last updated on: 2012-05-21

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