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Clinical Biochemistry

Code 10261
Year 3
Semester S1
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Química Medicinal
Mode of delivery Face-to-face
Work placements N/A
Learning outcomes Give students theoretical and practical training in the field of Clinical Chemistry
Prepare students for execution of a clinical and laboratorial study, as well as a correct interpretation of analytical results in different contexts
Develop student's accuracy of reasoning and demand of knowledge
-Know to apply the skills of biochemistry in the understanding of the disease and the action of drugs
-Familiarize with the biochemical and analytical parameters most commonly quantified in a laboratory
-Know how to perform laboratory techniques
-Working as a team and have a critical sense of their errors
-Be able to apply theoretical knowledge to the laboratory work and to the interpretation of results
-Understand the importance of Quality Controls

-Recognize clinical and laboratory situations associated to changes with different functions and physiologic and pathophysiologic systems
-Be able to interpret all the parameters analyzed in a laboratory of Clinical Chemistry
Syllabus Theoretical
1.Concept of Clinical Biochemistry
2.Analyses in Clinical Chemistry and Quality
2.1Types of analysis and biological samples
2.2Analytical errors. Importance of Quality Control in different laboratory stages
3.Biological fluids(BF)
3.1Differences in chemical composition
3.2Special Extravascular BF
4.Biochemical mechanisms and Laboratory parameters involved in the diagnosis of changes in:
4.1Renal Function
4.2Fluid and Electrolyte balance and acid-base
4.3Carbohydrate Metabolism
4.4Lipid Metabolism
4.5Liver Function
4.6Proteins/Enzymes

Practical
Determination blood glucose
Determination cholesterol, triglyceride and HDLc
Determination serum/urin protein. Interpretation of protein and lipiprotein electrophoresis
Determination urea, creatinine, uric acid
Determinations total bilirubin, alkaline phosphatase. Urinalysis, microscopic examination of urinary sediment
Presentation/discussion of clinical laboratory cases
Presentation of the final monography
Main Bibliography Basic Bibliography
- Burtis, C; Ashwood, ER; Tietz. Fundamentals of Clinical Chemistry, 5th Edition. W. Company, London (2001).
- Kaplan, LA; Pesce, AJ; Kazmierczak, SC. Clinical Chemistry: Theory, Analysis and Correlations, 4th Edition. MosbyInc, St Louis (2003).
- Bishop, LM; Fody, PE; Schoeff L. Clinical Chemistry: Principles, Procedures, Correlations, 5th Edition. Lippincott Williams and Wilkins, Baltimore (2005).
Supplementary Bibliography
- McPherson RA; Pincus MR. Henry’s Clinical Diagnosis and Management by Laboratory Methods, 22th Edition. Saunders, Elsevier (2012).
- Balcells A. La Clinica y el Laboratorio – Interpretacion de análisis y pruebas funcionales, 21th edicion. Elsevier Masson (2011).
- Devlin TM. Textbook of Biochemistry, with Clinical Correlations, 6th Edition. John Willey and Sons, Ltd, New York (2006).
- http://www.pubmed.com
- http://www.westgard.com
- http://www.ull.chemistry.uakron.edu
Language Portuguese. Tutorial support is available in English.
Last updated on: 2012-05-21

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