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Medicinal Chemistry II

Code 10262
Year 3
Semester S2
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Química Medicinal
Mode of delivery Face to face classes and in the form of self-learning by the student.
Work placements Not planned.
Learning outcomes This Medicinal Chemistry II Curricular Unit aims to provide current knowledge about the most commonly used drug families in clinical practice, particularly relating the chemical aspects with the pharmacology. At the end of this Curricular Unit, the student should be able to describe the chemical structures, discovery and development, main preparation methods, molecular mechanisms of pharmacological action, structure-activity relationship, pharmacokinetic aspects, basic therapeutic applications and limitations of the most used drug families in clinical practice. The student should also know the latest developments in the obtention of new bioactive molecules and new groups of drugs.
Syllabus Theoretical:
To know and understand, for the most useful drug families in clinical practice that interfere with peripheral and central nervous, cardiovascular, hormonal and immune systems and chemotherapeutic agents:
1. Chemical structures, nomenclature and main physicochemical properties
2. Discovery and development
3. Main preparation procedures
4. Molecular pharmacological and toxicological mechanisms of activity
5. Structure-activity relationship
6. Pharmacokinetics and its physicochemical and structural constraints
7. Therapeutic applications and basic limitations
8. New developments

Practical / Laboratory:
1. Main procedures for obtaining relevant drugs and / or its intermediates
2. Application of the most relevant analytical methodologies in drug synthesis and purification
3. Methodologies for the basic assessment of pharmacotoxicological activity
Main Bibliography Main bibliography:
1. T. L. Lemke, D. A. Williams, FOYE´s Principles of Medicinal Chemistry, 6th Ed., Lippincort Williams & Wilkins, 2008;
2. C. Avendaño, Introductión a la Química Farmacéutica, 2ª Ed., Mc.Graw-Hill, 2001;
3. G. L. Patrick, An Introduction to Medicinal Chemistry, 4th Ed., Oxford University Press, 2010;

1. R. B. Silverman, The Organic Chemistry of Drug Design and Drug Action, 2nd Ed., Elsevier Academic Press, 2004;
2. A. Delgado, C. Minguillón, J. Joglar, Introductión a la Síntesis de Fármacos, Sintesis, 2002;
Language Portuguese. Tutorial support is available in English.
Last updated on: 2012-05-21

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