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  4. Genetics


Code 10266
Year 3
Semester S2
ECTS Credits 6
Workload TP(60H)
Scientific area Química Medicinal
Mode of delivery Tutorial
Work placements does not apply
Learning outcomes The main goal of this curriculum unit is to introduce the student into the general concepts of contemporary Genetics The student will be able to:
-learn, how to apply the fundamental concepts of genetics
- understand and explain the molecular and cellular processes involved in the transmission of hereditary characteristics and to know how to discuss them
- apply Molecular genetic analysis tools
- manipulate nucleic acids
Syllabus Theoretical program
Formal Bases of Mendelian theory. InheritanceMendelian and non memdelian. segregation analysis. factorial link: recombinant fraction. Hardy-Weinberg formalism; homogametic and heterogametic loci. Models for Populational genetics. Cytogenetics chromosome Theory of heredity. Chromatin; chromosomes-organization in prokaryotes and eukaryotes. Vectors. Y chromosome and mtDNA. Chromosome mutations: numeric and structure. Organization and evolution of chromosomes. Biochemical genetics and Molecular metabolism inborn errors. Hypothesis "one gene-one enzyme". Metabolic chains: epistase and hipostase. Collinearity between gene and protein. Structure and organization of the genetic material. Replication, transcription and translation. Control of gene expression.

Practical program
Nucleic acids extraction and purification
PCR assays
Main Bibliography Main references:
- Genetics a conceptual approach. Benjamin A. Pierce. W. H. Freeman, 2ª edição, 2006

- An Introduction to Genetic Analysis. A.J.F. Griffiths. W. H. Freeman, 7th ed, 2002
- Genetics - Analysis of genes and genomes. Daniel L. Hartl and Elizabeth W Jones. Jones and Bartlett, 2005
- Principles of genetics. Robert H. Tamarin. McGraw-Hill, 7th ed, 2004
- Complementar references will be given to the student if necessary

Language Portuguese. Tutorial support is available in English.
Last updated on: 2012-05-21

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