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Medicinal Chemistry
Advanced Medicinal Chemistry

Advanced Medicinal Chemistry

Code	11126
Year	1
Semester	S1
ECTS Credits	6
Workload	PL(26H)/T(30H)/TP(4H)
Scientific area	Química Medicinal
Entry requirements	To have knowledge on General, Inorganic, Organic and Medicinal Chemistry, as well as Human Biology and Physiology.
Mode of delivery	Presencial classes
Learning outcomes	This Curricular Unit provides scientific and technical knowledge on advanced topics in Medicinal Chemistry, concerning the early stages of the development of new medicines, specifically in the area of design/development, preparation and basic biological evaluation of potentially new drugs. This Curricular Unit aims that students can design/develop new drugs and modulate their potential pharmacotoxicological activity, including important families of compounds as metals/metal complexes, antioxidants and bioactive structures based on heterocycles and sugars.
Syllabus	Theorethical: 1. Modern and advanced approaches in drug discovery/development 1.1. Target-oriented approach in drug discovery process and other strategies 1.2. Signal transduction pathways as targets for drug discovery 1.3. Target identification, hit identification and lead optimization 1.4. Combinatorial and parallel chemistry in drug discovery 1.5. Prediction/monitorization of pharmacokinetic and toxicity properties 1.6. Drug delivery and distribution and its modulation 2. Metals/metal complexes in medicinal chemistry 3. Medicinal chemistry of free radicals and development of antioxidants 4. Carbohydrate chemistry in drug design 5. Heterocyclic chemistry in drug design Theoretical-practical/Laboratorial: -Synthesis/characterization of bioactive compounds based on carbohydrates or heterocycles -Prediction/monitorization of pharmacokinetic and toxicity properties in drug discovery
Main Bibliography	- C. G. Wermuth, The Practice of Medicinal Chemistry, 3rd Ed., Academic Press, 2008; - T. L. Lemke, D. A. Williams, FOYE´s Principles of Medicinal Chemistry, 6th Ed., Lippincott Williams & Wilkins, 2008; - G. L. Patrick, An Introduction to Medicinal Chemistry, 4th Ed., Oxford University Press, 2010; - T. K. Lindhorst, Essentials of Carbohydrate Chemistry and Biochemistry, 3rd Ed., Wiley-VCH:Weinheim, 2007; - A. Varki, R. D. Cummings, J. D. Esko, H. H. Freeze, P. Stanley, C. R. Bertozzi, G. W. Hart, M. E. Etzler, Essentials of Glycobiology, 2nd Ed., Cold Spring Harbor Lab. Press: New York, 2009. - artigos científicos da área com peer-review.
Language	Portuguese. Tutorial support is available in English.