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Medicinal Chemistry
New Synthetic Processes

New Synthetic Processes

Code	12036
Year	1
Semester	S2
ECTS Credits	6
Workload	PL(30H)/T(30H)
Scientific area	Química Medicinal
Mode of delivery	Face-to-face
Work placements	Not applicable
Learning outcomes	This Curricular Unit (UC) aims to provide current knowledge on new chemical processes and synthetic strategies and their application in laboratorial and industrial preparation of molecules of therapeutic interest and/or their synthetic intermediates. At the end of the UC, it is intended that the student knows how to apply metrics in Green Chemistry and how to evaluate the industrial processes for the chemical preparation of drugs, and to develop and apply new processes with interest for the Chemical-Pharmaceutical Industry, mainly in the preparation of Active Pharmaceutical Ingredients (APIs).
Syllabus	THEORETICAL PROGRAM 1. Introduction to (Pharmaceutical) Green Chemistry 2. Metrics in Green Chemistry 3. Regulatory and Environmental Issues 3.1. Chemical waste and environmental impact 3.2. Legislation on Green Chemistry 4. Green synthetic techniques 4.1. Catalysis 4.2. Alternative solvents 4.3. Alternative energetic sources 4.4. Sustainable reactants 4.5. Combinations and other techniques/strategies 5. Pharmaceutical Green Chemistry and Pharmaceutical Industry 5.1. Green Chemistry strategies and their planning 5.2. Purification and analysis 5.3. Industry of generic medicines 5.4. Continuous processes and Green Engineering 6. Practical cases PRACTICAL/LABORATORIAL PROGRAM 1. Metrics in Green Chemistry – practical cases 2. Laboratorial cases 2.1. Oxidation 2.2. Acylation 3.3. Methylation 2.4. Multi-component reactions
Main Bibliography	- Green Techniques for Organic Synthesis and Medicinal Chemistry, Wei Zhang, and Berkeley W. Cue (Editors), Wiley, 2012. - Green Chemistry in the Pharmaceutical Industry, Peter J. Dunn, Andrew S. Wells, and Michael T. William (Editors), Wiley-VCH, 2010. - Eco-Friendly Synthesis of Fine Chemicals, Roberto Ballini (Editor), RSC, 2009. - Artigos de revistas científicas.
Language	Portuguese. Tutorial support is available in English.