| Code |
13417
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| Year |
3
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| Semester |
S1
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| ECTS Credits |
6
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| Workload |
PL(30H)/T(30H)
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| Scientific area |
Biomedical Sciences
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Entry requirements |
None.
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Mode of delivery |
Face-to-face.
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Learning outcomes |
In this course unit, the aim is that students learn to describe and integrate the knowledge on the organs and the cellular and molecular components of the human Immunitary System, its organization and diversity, as well as specialized functions.
At the end of the course, the student should be able to:
1. Distinguish cells, molecules, and pathways of induction and regulation of the Innate and adaptative Immune responses (both cellular and humoral);
2. Describe the mechanisms and the more relevant aspects of the structure, dynamics, and functions of the innate and adaptive immunological system in humans, trying to integrate the concepts acquired in an immunopathological context;
3. To fundament and execute some of the main laboratory techniques used in research and routine laboratories and their practical applications;
4. To interpret and present scientific data and research articles through the use of immunological techniques;
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Syllabus |
1. Dynamics of the Immune System
2. Components of the Immune System
3. Innate Immunity
2.1. NK cells and phagocytic cells: characteristics, activation, and function
2.2 Inflammation and Complement System
4. Structure and function of MHC-I and -II and antigenic presentation pathways
5. Cell-mediated Immunity: ontogeny and activation of T cells
5.1. Phenotypic and functional aspects of T cell populations
6. Humoral Immunity
5.1. Ontogeny and B cell activation
5.2. Immunoglobulins (Igs): diversity, characteristics, functions, isotype switching, and affinity maturation
7. Central and peripheral Immune tolerance
8. Immunosenescence
PRACTICAL CLASSES
1. Blood leukocyte morphology, their isolation, phenotyping by flow cytometry, and determination of cell concentration and viability
2. Techniques based on the interaction Antigen-Antibody
3. Histology of lymphoid tissues
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Main Bibliography |
“Cellular and Molecular Immunology” Abul Abbas, Andrew H. Lichtman, Shiv Pillai. Elsevier (10ª ed; 2022)
“Basic Immunology-functions and disorders of the immune system” Abul Abbas, Andrew H. Lichtman, Shiv Pillai. Elsevier (7ª ed; 2023)
“Textbook of Medical Physiology”. Guyton and Hall; Saunders (14th ed.; 2020)
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Teaching Methodologies and Assessment Criteria |
The assessment criteria include:
- 2 tests on the theoretical component (TT), media value: 80% of the final mark (T1=30% and T2=70%)
- Participation in class (P) and online activities: 5%, 1 in 20 values (0 values <30%, 10 values between 30% and 70%, and 20 values > 70%)
- Weekly Portfolio (Pf): 5%
- Analysis of a scientific article (SA) with oral presentation: 10%
Final mark= (TT x 0,80) + (Pf x 0,05) + (SA x 0, 10) + (AC x 0,15)
Exam: contributes to 80%, because 20% comes from the continuous evaluation.
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Language |
Portuguese. Tutorial support is available in English.
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