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Biochemistry I

Code 13645
Year 2
Semester S1
ECTS Credits 6
Workload PL(15H)/T(30H)/TP(15H)
Scientific area Ciências Biológicas e Biomédicas
Entry requirements Not applicable.
Mode of delivery Face to face lectures.
Work placements Not applicable
Learning outcomes This Course aims to provide students with a set of knowledge in the area of basic biochemistry that enable them to understand the molecular logic of life.
At the end of this course the student should be able to:
-Identify the general principles and terminology of Biochemistry;
-Recognize and describe the structure and properties of biomolecules;
-Explain the relation between the structure and properties of biomolecules and their biological function;
-Identify and describe the basic principles of enzymology and enzyme mechanisms;
-Apply the acquired knowledge to interpret and to solve problems in the field of Biochemistry;
-Perform experimental techniques in the field of Biochemistry and analyze and interpret the results accurately and critically
Syllabus 1 INTRODUCTION TO BIOCHEMISTRY. Origin of biomolecules. The water molecule (properties and buffer solutions).
2 PROTEINS. Structure and properties of amino acids. Stereochemistry and acid-base properties. Hierarchy and structural classification of proteins. Structure and function of proteins. Allosteric proteins: hemoglobin. Purification and characterization of proteins. Properties of enzymes.
3-CARBOHYDRATES. Structure and general properties. Stereoisomerism, mutarotation and anomeric forms.
4. LIPIDS. Classification, structure and properties.
5. NUCLEIC ACIDS. Structure, properties and function. Plasmids.
6. VITAMINS AND COENZYMES. General features of water-soluble and fat soluble vitamins. Structure and biological role of vitamins. Coenzymes.
7.EXPERIMENTAL
Preparation and testing of buffer solutions.
Potentiometric titration of amino acids.
Determination of protein concentration by Bradford method.
Study of the kinetics of sucrose hydrolysis by the enzyme invertase.
Main Bibliography -D.L. Nelson e M.M. Cox (2017) Lehninger Principles of Biochemistry: International Edition, 7th ed., W.H.Freeman & Co Ltd..
- J.M. Berg, J.L. Tymoczko, L. Stryer (2015) Biochemistry. 8th ed., New York: Freeman
-A.Quintas, A.P Freire, M.J. Halpern, (2008) Bioquímica - Organização Molecular da Vida, Ed. Lidel
-D. Voet, J.G. Voet (2011). Biochemistry. 4th ed., New York: John Wiley & Sons
Language Portuguese. Tutorial support is available in English.
Last updated on: 2021-01-27

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