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Pharmacognosia II

Code 13646
Year 2
Semester S1
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Ciências Farmacêuticas
Entry requirements N/A
Mode of delivery Face-to-face.
Work placements Not applicable.
Learning outcomes In this course unit it is intended that the student identifies the chemical constituents of the secondary metabolism of medicinal plants and relate this compounds to their chemical and biological properties. At the end of the course unit the student should be able to identify and relate the chemical constituents of the secondary metabolism of medicinal plants with their chemical and biological properties. To identify the different groups of compounds of the secondary metabolism of the plants and understand their distribution in nature, extraction methods, quality control, chemical structure and structure-activity interaction.
Syllabus Theoretical: 1. Phenolic compounds: phenolic acids; Coumarins; Lignans; stilbenes; Flavonoids; Anthocyanosides Tannins; Quinonic compounds; Orcinols and Floroglucinols 2. Terpenoids and steroids: essential oils; Iridoids; Diterpenes; Saponosides;cardiotonics; Carotenoids 3. Alkaloids: alkaloids derived from ornithine and lysine; Alkaloids derived from nicotinic acid; Alkaloids derived from phenylalanine and tyrosine; Tryptophan-derived alkaloids; Alkaloids derived from hystidine; Alkaloids derived from therpenic metabolism; Methylxanthines. Laboratory: Determination of free and combined anthraquinonics; Determination of alkaloids with general reagents of Dragendorf, Mayer and Bertrand; Alkaloids alcalimmetric dosing; Soxhlet extraction of different plants; Generic identification and chromatographic profile of flavonoids in extracts; Spectrophotometric quantification of flavonoids and phenolic compounds; Determination of essential oil in the Clevenger apparatus
Main Bibliography Pharmacognosie, phytochimie, plantes médicinales, Bruneton, J., Editions Techniques et Documentation, 4eme edition, 2009. Farmacognosia e fitoquímica , Proença da Cunha, A. (Ed.), Fundação Calouste Gulbenkian, 2005. Trease and Evans Pharmacognosy, Evans, W.C., Edinburgh: Saunders , 2002. Farmacopeia Portuguesa, 1º e 2º vol., 9ª Ed oficial, Ministério da Saúde, INFARMED, 2008. Farmacognosia - Farmacognosia experimental, Costa, A. F., Fundação Calouste Gulbenkian, 3ª ed., 2001.
Teaching Methodologies and Assessment Criteria Lectures: 2 hours / week. Master classes with power point presentations with previous distribution to students. Laboratory classes: 2 hours / week. The protocols of the laboratory works and their theoretical explanation are distributed to students at the beginning of the semester. Students should work in groups of two. At the beginning of the semester it will be defined by the professor a schedule for tutorial hours for students (2 hours / week).Periodic evaluation: I. Written Evaluation: 2 partial tests (80% theoretical questions + 20% practical questions). II. Assistance to a seminar with evaluation III. Monograph on a free theme based on scientific articles with presentation. 2. Frequency criteria: Students must perform all practical work; Students must participate in all partial tests and obtain a minimum average score of 6 values to participate in the final exam;
Language Portuguese. Tutorial support is available in English.
Last updated on: 2021-01-27

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