Pharmacognosia II

Code	13646
Year	2
Semester	S1
ECTS Credits	6
Workload	PL(30H)/T(30H)
Scientific area	Ciências Farmacêuticas
Entry requirements	N/A
Mode of delivery	Face-to-face.
Work placements	Not applicable.
Learning outcomes	In this course unit it is intended that the student identifies the chemical constituents of the secondary metabolism of medicinal plants and relate this compounds to their chemical and biological properties. At the end of the course unit the student should be able to identify and relate the chemical constituents of the secondary metabolism of medicinal plants with their chemical and biological properties. To identify the different groups of compounds of the secondary metabolism of the plants and understand their distribution in nature, extraction methods, quality control, chemical structure and structure-activity interaction.
Syllabus	Theoretical: 1. Phenolic compounds: Phenolic acids; Coumarins;Lignans; Stilbenes; Flavonoids; Curcuminoids; Tannins; quinonic compounds; orcinols and phloroglucinols 2. Terpenoids and steroids: essential oils; Iridoids; Diterpenes; Saponosides and Cardiotonics; Carotenoids 3. Alkaloids: Distribution and location; Main biological activities and therapeutic uses; Classification and important examples: Alkaloids with an amine group in the side chain; Alkaloids with pyrrolidine, pyridine and piperidine nuclei; Alkaloids with a tropane nucleus; Alkaloids with a pyrrolizidine nucleus; Alkaloids with quinolizidine nucleus; Quinoline alkaloids; Alkaloids with isoquinoline; Alkaloids with an indole nucleus; Alkaloids derived from terpene metabolism (diterpene alkaloids and steroids); other alkaloids. Methylxanthines.
Main Bibliography	Pharmacognosie, phytochimie, plantes médicinales, Bruneton, J., Editions Techniques et Documentation, 4eme edition, 2009. Farmacognosia e fitoquímica , Proença da Cunha, A. (Ed.), Fundação Calouste Gulbenkian, 2005. Trease and Evans Pharmacognosy, Evans, W.C., Edinburgh: Saunders , 2002. Farmacopeia Portuguesa, 1º e 2º vol., 9ª Ed oficial, Ministério da Saúde, INFARMED, 2008. Farmacognosia - Farmacognosia experimental, Costa, A. F., Fundação Calouste Gulbenkian, 3ª ed., 2001.
Teaching Methodologies and Assessment Criteria	Lectures: 2 hours / week. Master classes with power point presentations with previous distribution to students. Laboratory classes: 2 hours / week. The protocols of the laboratory works and their theoretical explanation are distributed to students at the beginning of the semester. Periodic evaluation: I. Written Evaluation: 2 partial tests (80% theoretical questions + 20% practical questions). II. Monograph on a free theme based on scientific articles with presentation. 2. Assessment methodology: I. The partial tests will focus on the concepts acquired in theoretical and practical classes and will consist of 40 multiple choice questions, 32 theoretical and 8 practical. Questions answered incorrectly will be deducted 10% of the value of the question. II. The free-topic bibliographic research monograph must apply knowledge of Pharmacognosy I and II, based on the analysis of a current scientific article, chosen by the students or from a group provided by the teacher through Moodle.
Language	Portuguese. Tutorial support is available in English.