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  4. Toxicology


Code 13665
Year 4
Semester A1
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Ciências Farmacêuticas
Entry requirements knowledge of analytical methods and pharmacology
Mode of delivery - THEORETICAL CLASSES Magistral and tutorial classes (assistance is mandatory, and a maximum of 15% nonattendance is allowed), following the program defined in accordance with the objectives. - LABORATORIAL CLASSES Tutorial classes, conducted by a professor (assistance is mandatory), to revise in depth some of the themes learned in the magistral classes, using an experimental approach.
Work placements Not applicable
Learning outcomes . Basic knowledge on Toxicology, and on the main factors influencing toxicity.
. To understand the importance of drug interactions and their effect on the toxic phenomenon.
. To know the basic techniques used in Toxicology and their applications.

At the end of the curricular unit the student should be able to:
Have an adequate understanding of toxicological concepts; Describe adequately the stages of the toxic process; Understand the biotransformation processes in the living being; Evaluate the toxic effects and perform the most adequate tests; Know the mechanisms of drug interactions and their toxic effects; Use the methods and techniques needed for the toxicological research, particularly in what concerns basic and analytical aspects; Know and use general tools of the scientific approach and use basic toxicology-related sources of information.
Syllabus Theoretical Program (modules)
UP1- Introduction to Toxicology
UP2- Forensic and Clinical Toxicology, Types of Samples, and Methodologies
UP3- Toxicity of Toxic and Potentially Toxic Metals
UP4- Toxicity of Gases, Solvents, and Vapors
UP5- Toxicity of Pesticides
UP6- Toxicity of Pharmaceuticals
UP7- Toxicity of Drugs of Abuse
UP8- Drug-Facilitated Sexual Assault
UP9- Laboratory Analysis

Laboratory Program:
T1: Determination of Salicylates, Alkaloids, and Barbiturates in Urine Samples
T2-3: Determination of Heavy Metals in Water Samples by Atomic Absorption Spectroscopy
T4: Determination of Xenobiotics by Gas Chromatography/Mass Spectrometry in Tandem
T5: Determination of Paraquat in Urine Samples
T6: Research of Toxic Substances in the Context of Clinical/Forensic Toxicology: Case Analysis
T7: Determination of Adulterants in Drugs of Abuse
Main Bibliography Klaassen CD, Amdur MO, Doull J.Casarett & Doull's Toxicology: The Basic Science of Poisons. 9thEd, New York, McGraw-Hill, 2019. Clarke EGC.Clarke’s Isolation and Identification of drugs. 4thEd, London, Pharmaceutical Press, 2011. Hayes AW.Principles and methods of toxicology. 6ª Ed, Philadelphia, CRC Press, 2014. Baselt RC.Disposition of Toxic Drugs & Chemicals in Man. 12thEd, Foster City, CA, Biomedical Publications, 2020. Ellenhorn MJ.Ellenhorn’s Medical Toxicology: Diagnosis and Treatment of human poisoning. 2ªnd, Baltimore, Willians & Wilkins, 1997. Gisbert Calabuig JA, Villanueva Cañadas E.Medicina legal y toxicología. 7thEd, Barcelona,Masson, 2018. Gallardo E, Queiroz JA. The role of alternative specimens in toxicological analysis.Biomed. Chromatogr. 2008;22:795-821. Jefferey GH, et al. Vogel:Análise Química Quantitativa, 6thEd, Rio de Janeiro, Guanabara-Koogan, 2002. Skoog D, et al.Fundamentals of Analytical Chemistry, 9thEd, Fort Worth, Saunders College Publishing, 2013.
Teaching Methodologies and Assessment Criteria Classification of Teaching Learning: (Factor a x 0,40) + (Factor b x 0,60)
Factor a) Practical assessment (final grade greater than or equal to 9.5 points) with a relative weight of 40% in the final classification. Final score of the practical grade (PL) =Laboratorial component: classification of the evaluation of the knowledge acquired in the practical component (60%); performance in the laboratory through posture and ease in laboratory execution (35%) and punctuality (5%). The students must have at least 9.5/20 points in order to approve. Failure to pass in practice will imply failure of the curricular unit.

Factor b) Written test with a weight of 60% (minimum mark of 9.5 points). Final mark of 9.5 or more.
This component is subdivided into three exams: Assessment UP1-UP3 (relative weight 30%); UP4-UP5 assessment (relative weight of 30%); UP6-UP9 assessment (relative weight of 40%).

Language Portuguese. Tutorial support is available in English.
Last updated on: 2024-01-20

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