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Syllabus |
Theoretical:
A) Introduction to the general molecular basis of drug action:
1. Development of receptor agonists and antagonists, enzyme inhibitors and nucleic acid interacting agents
2. General relationship between drug structure and pharmacokinetics
3. Drug metabolism, chemical mechanisms of bioactivation and prodrugs
B) For the major drug families of clinical interest, address:
1. Structures, nomenclature and main physicochemical properties
2. Discovery, development and general processes for their obtention
3. Molecular mechanisms of pharmacological action
4. Structure-activity relationships
5. Physico-chemical and structural aspects conditioning pharmacokinetics
Practical / Laboratory:
1. Prediction of drug metabolism and prodrug development
2. Obtention of relevant drugs and / or their intermediates
3. Pharmaceutical and pharmacopoeial drugs analysis
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Main Bibliography |
1. T. L. Lemke, D. A. Williams, FOYE´s Principles of Medicinal Chemistry, 7th Ed., Lippincort Williams & Wilkins, 2013;
2. G. L. Patrick, An Introduction to Medicinal Chemistry, 4th Ed., Oxford University Press, 2010;
3. R. B. Silverman, The Organic Chemistry of Drug Design and Drug Action, 2nd Ed., Elsevier Academic Press, 2004;
4. C. Avendaño, Introductión a la Química Farmacéutica, 2ª Ed., Mc.Graw-Hill, 2001;
5. T. Nogrady, D. F. Weaver, Medicinal Chemistry – A Molecular and Biochemical Approach, 3rd Ed., Oxford University Press, 2005;
6. A. Delgado, C. Minguillón, J. Joglar, Introductión a la Química Terapéutica, 2ª Ed., Diaz de Santos, 2003;
7. A. Delgado, C. Minguillón, J. Joglar, Introductión a la Síntesis de Fármacos, Editorial Sintesis, 2002;
8. C. Dickson, Medicinal Chemistry Laboratory Manual, CRC Press: Boca Raton, London, New York, Washington DC, 1999;
9. http://old.iupac.org/publications/cd/medicinal_chemistry/
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