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Course of New Production Processes of Drugs

Code 13698
Year 4
Semester S2
ECTS Credits 3
Workload PL(15H)/T(15H)
Scientific area Ciências Farmacêuticas
Entry requirements To have basic knowledge on general and organic chemistry.
Learning outcomes This Curricular Unit (UC) aims to provide, in a pharmaceutical perspective, current knowledge about new synthetic processes and their application in the laboratory and industrial preparation of molecules of therapeutic interest and/or their synthesis intermediates. At the end of the course, it is intended that the student knows how to apply the (Pharmaceutical) Green Chemistry metrics and how to evaluate the processes for the chemical preparation of drugs. In addition, the student should know how to develop and apply new synthetic processes with interest in the Pharmaceutical Chemical Industry, especially in the preparation of “Active Pharmaceutical Ingredients ”(APIs).
Syllabus 1. Introduction to Green (Pharmaceutical) Chemistry 1.1. Definitions and concepts 1.2. Synthetic process development and drug production 1.3. Green Chemistry Principles and Drug Production 2. Metrics in Green Chemistry 3. Environmental and Regulatory Aspects 3.1. Chemical waste and environmental impact 3.2. Green Chemistry Legislation 4. Green / Sustainable Synthetic Techniques 4.1. Catalysis 4.2. Alternative solvents 4.3. Alternative energy sources 4.4. Sustainable reagents 4.5. Combinations and other techniques / strategies 5. Green Pharmaceutical Chemistry and Pharmaceutical Industry 5.1. Strategies and planning 5.2. Purification and analysis 5.3. Generic drug industry 5.4. Continuous processes and “Green Engineering” 6. Practical application cases PRACTICAL / LABORATORY PROGRAM 1. Application of metrics in Green Chemistry 2. Laboratory application cases 2.1. Acylation 2.2. Oxidation
Main Bibliography -Green Techniques for Organic Synthesis and Medicinal Chemistry, Wei Zhang, and Berkeley W. Cue (Editors), Wiley, 2012.
-Green Chemistry in the Pharmaceutical Industry, Peter J. Dunn, Andrew S. Wells, and Michael T. William (Editors), WileyVCH, 2010.
-EcoFriendly Synthesis of Fine Chemicals, Roberto Ballini (Editor), RSC, 2009.
-J.A.R. Salvador, R.M.A. Pinto, S.M. Silvestre, “Pharmaceutical Green Chemistry Applied to the Chemical Synthesis of Steroid Compounds”, Current Green Chemistry, 2015, 2(2): 97134.
-R.M.A. Pinto, S.M. Silvestre, “Pharmaceutical Green Chemistry: Is Just Green Chemistry or Is Something Else More?”, Journal of Chemical Engineering and Chemistry Research, 2014, 1(5): 290301.
-Outros artigos de revistas científicas
Language Portuguese. Tutorial support is available in English.
Last updated on: 2021-06-24

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