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Course of Instrumental Methods and Techniques of Clinical and Toxicological Analysis

Code 13705
Year 5
Semester S1
ECTS Credits 3
Workload PL(10H)/T(12H)/TP(8H)
Scientific area Ciências Farmacêuticas
Entry requirements Attend or have attended Pharmaceutical Sciences couse. Prior knowledge of toxicology, clinical analysis and analytical methods
Learning outcomes Provide the students with an integrated view of the basic principles of laboratory equipment, instrumental techniques and the analytical methodologies most commonly used in the field of bioanalytical applications in the laboratories of toxicology and clinical analysis. The ultimate objective is for students to gain a deeper understanding of the technical/technological aspects of all laboratory activities, namely developing skills for an adequate and efficient use of laboratory equipment, with a good knowledge of the basic operating principles, and for the efficient optimization, implementation, validation and quality control of analytical methods. This UC will provide the basis for the development of a future professional activity in a clinical laboratory in the fields of toxicology and clinical analysis, contemplating the advances that have occurred in the last years in both instrumental and molecular techniques.
Syllabus Introduction - The Laboratory of Toxicology and Clinical Analyses 1 - Laboratory terminology. Analytical methodologies: Development and validation of methods of analysis and basic applied statistics. Quality control. Legislation concerning manufacture and placing on the market. EC declaration of conformity. 2 - Instrumental techniques - Basic principles of operation and examples of use: Techniques. 3 - Automation. Historical perspective and technological developments. General concepts about automation: Practical component. The practical component of the curricular unit will consist of laboratory work to highlight the basic principles of instrumentation operation and to carry out procedures for concepts’ application, namely those related to the development and validation of analytical methods.
Main Bibliography Guidelines to Clinical and Laboratory Standards Institute.
Guideline on bioanalytical method validation- European Medicines Agency (EMA).

Guideline on bioanalytical method validation- Food and Drug Administration (FDA).
Guidelines to Scientific Working Group for Forensic Toxicology (SWGTOX).
Gerald J. Kost (Ed). ; Handbook of Clinical Automation, Robotics, and Optimization. , Wiley-Interscience, 1996
Michael G. Bissell and John R. Petersen; Automated Integration of Clinical Laboratories: A Reference, AACC, 1998
J.M. González de Buitrago. Técnicas y Métodos de Laboratorio Clínico. 3ª Edición. Elsevier España, 2010.
Robert J. Flanagan et al. Fundamentals of Analytical Toxicology. John Wiley & Sons, 2007.
Rosado T, Soares S, Mlaca S, Gonçalves J, Barroso M, Gallardo E. The Role of liquid Chromatography in toxicological Analysis. In: High- performance liquid Chromatography: types, parameters and applications. Nova Sciences Publishers, 2018.
Teaching Methodologies and Assessment Criteria
Methods of evaluation: group work (50%), laboratory performance (20%) and a written test related to theoretical contents (30%).
Language Portuguese. Tutorial support is available in English.
Last updated on: 2020-01-15

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