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Blood and Immune System

Code 15117
Year 2
Semester A1
ECTS Credits 6
Workload OT(46H)/PL(6H)/S(4H)
Scientific area Morphological and Functional Sciences
Entry requirements None.
Learning outcomes At the end of this course unit, students should me able to: 1) to correlate the hematopoiesis phases with the morphological and functional characteristics of blood cells, 2) to recognize the blood components and to diferentiate their actions in the organism, 3) distinguish the steps and mechanisms of hemostasis and coagulation. In what regards the Immune System (IS), the learning outcomes are: 1) to describe and integrate theknowledge about the organs, cells and molecules of the IS, its organization and diversity, as well as its specialized functions, namely the pathways involved in the induction and regulation of an inate and adaptative normal physiological response.
Syllabus Blood (pedagogical unit 1): hematopoiesis, componentes and functions of the blood and hemostasis.
Immune Sytem (pedagogical units 2 and 3):
1.Dynamics of the SI
2.Components of the SI
3.Inate responses:
3.1. NK and phagocytic cells: characteristics, activation and funcion
3.2 Inflammation and System of the Conplement
4. Structure and function of MHC molecules and antigen presentation mecanisms pathways
5.Cellular immune responses: ontogeny and activation of T cells
5.1 phenotypical and functional aspects of T cell populations
6.Hummoral imune responses: ontogeny and activation of B cells
6.1 Immunoglobulins (Igs): diversity, characteristics, functions, isotype changes andaffinity maturation
7. Central and peripheral immunological tolerance.
Practical classes consists in: morphological analysis of blood leucocytes in blood smear examination with microscopes, agglutination latex-based and hemagglutination techniques, histological identification of lymphoid organs.
Main Bibliography Cellular and Molecular Immunology” Abul Abbas, Andrew H. Lichtman, Shiv Pillai. Elsevier (9ª ed; 2018)
“Saladin: Anatomy & Physiology: The Unity of Form and Function”; McGraw-Hill (8ª ed; 2018)
“Henry’s Clinical Diagnosis and Management by Laboratory Methods”; Richard A. McPherson, Matthew R. Pincus; Saunders / Elsevier (23ª ed; 2016);
“Hoffbrand´s Essential Haematology”; A.V. Hoffbrand, P.A.H. Moss; Artmed (7ª ed; 2016);
Essentials of Clinical Immunology, 6th Edition. Chapel H, Haeney M, Misbah S, Snowden N. Wiley-Blackwell
“Textbook of Medical Physiology”. Guyton and Hall; Saunders (12th ed.; 2016)
Teaching Methodologies and Assessment Criteria In this course unit student-centered teaching methodologies are adopted. With the aim to promote the understanding of the relevant of the themes, the students discuss problems in groups and the discussion about their resolution is incentivated. In practical classes, the students have the opportunity to execute laboratory techniques relevant for the understanding of the Immune System components and mecanisms. In this contexto, the knowledge is assessed through written tests consisting in multipe-choice questions aligned with the proposed learning objectives.
Language Portuguese. Tutorial support is available in English.
Last updated on: 2022-06-21

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