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Chemical and Biological Analysis for Clinical Application

Code 17233
Year 1
Semester S2
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Biochemistry
Entry requirements Not applicable.
Learning outcomes Prepare the student for contact with a Clinical Analysis Lab (CAB)
Provide theoretical and practical training in the CA area
Provide clinical-laboratory knowledge for integration into specific/multidisciplinary teams
Consolidate basic training, constituting an extension to areas of specialization
Understanding the hierarchy of the CAB
Knowing how to apply knowledge from all areas in understanding disease/drug action
Knowing how to perform laboratory techniques of increasing complexity
Acquiring practical skills, particularly in microscopy
How to interpret External Quality Assessment (EQA) results
Knowing how to apply statistical knowledge in Quality Assessment
Identifying/recognizing changes in analytical parameters
How to interpret an analytical request, contextualize laboratory changes in different pathologies, and integrate underlying mechanisms and how to identify emergency situations
Using scientific reasoning in self-learning
Understanding/integrating resolution clinical cases
Syllabus UP1-LAC: Evolution/Quality
UP2-1 Hematology
1.1 Hematopoiesis
1.2 Erythrocyte, leukocyte, platelet: associated pathologies
1.3 Hemostasis: evaluation
2 Clinical Chemistry - Microbiology, Immunology, Endocrinology:
2.1 Diabetes; Alterations in renal/lipid function in diabetics
2.2 Diabetes and CVD markers
2.3 Renal function
2.4 Urinary tract infection
2.5 Renin-angiotensin-aldosterone system
2.6 Other regulatory hormones
2.7 Hepatitis: Etiology/Diagnosis. Importance of hepatitis, cytomegalovirus, rubella, toxoplasmosis in pregnant women
3 Tumor markers: Importance/interpretation
TP/PL
Interpretation of analytical request
Complete blood count, platelets: manual/automatic count
Interpretation of histograms and cytograms
Description of Wintrobe and Westergren techniques
Execution of blood smears
Differential count of leukocytes and reticulocytes
Quantification of HbA1c, thyroid hormones
Urinalysis: type II/bacteriological
Interpretation of results and resolution of practical cases
Main Bibliography Basic Bibliography:
-McPherson RA; Pincus MR. Henry’s Clinical Diagnosis and Management by Laboratory Methods, 23rd Edition. Saunders, Elsevier (2017).
-HillmanRS; Hematology in clinical practice: a guide to diagnosis and management, 4th Edition. McGraw-Hill, USA, (2005)
-Guyton AC; Hall JE. Textbook of Medical Physiology, 11th Edition. Publisher: Elsevier (2006)

Complementary Bibliography
Bishop, LM; Fody, PE; Schoeff L. Clinical Chemistry: Principles, Procedures, Correlations, 8th Edition. Lippincott Williams & Wilkins, Baltimore (2018)
Teaching Methodologies and Assessment Criteria n/a
Language Portuguese. Tutorial support is available in English.
Last updated on: 2026-01-12

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