| Code |
17247
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| Year |
1
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| Semester |
S1
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| ECTS Credits |
6
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| Workload |
TP(60H)
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| Scientific area |
Biochemistry
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|
Entry requirements |
Basic knowledge in cell biology and biochemistry
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Learning outcomes |
To obtain knowledge about the molecular and cellular basis of cancer, to recognize the importance of basic research in the evolution of clinical applications in oncology, to know how to perform some laboratory techniques used in cancer research.
Students should acquire the conceptual and practical bases to carry out research in oncobiology. They should understand the onset and progression of oncological diseases and feel able to discuss and develop strategies to develop research in this field, and perform technical functions in a laboratory environment. It is also expected that they will be able to solve problems associated with the topics analyzed, showing the ability to apply knowledge to practice. In terms of attitudes, students should have developed the ability to work as a team in solving problems and acquiring knowledge.
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Syllabus |
Characterization of benign and malignant tumors: classification, evolution and histology
Cancer-causing agents: concept of carcinogen and mutagens, environmental factors, lifestyle factors, heredity, viruses and bacteria with transforming action, reproductive and sexual behaviour
Cell Cycle Control
Oncogenes
Tumor suppressor genes
Apoptosis
Importance of telomeres in cellular senescence and cell immortalization
Genomic instability and cancer
Extracellular matrix, cell adhesion and cancer
Angiogense
Metastasis of tumors
Cancer stem cells
LABORATORY TECHNIQUES
1. Simple stains and immunohistochemistry.
2. Cell line culture
3. Cell proliferation assay
4. Apoptosis Assays
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Main Bibliography |
Weinberg R A (2014) The Biology of Cancer, Garland Science, Whitehead Institute for Biomedical Research Ed., 864p
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Language |
Portuguese. Tutorial support is available in English.
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