| Code |
17257
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| Year |
1
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| Semester |
S2
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| ECTS Credits |
6
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| Workload |
PL(30H)/T(30H)
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| Scientific area |
Biochemistry
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Entry requirements |
N.A.
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Learning outcomes |
The Bionanosystems course unit aims to provide students with a comprehensive overview of nanoscale technologies and their applications in the therapeutic and imaging fields.
At the end of this course unit, the students should be able to:
1. Describe the importance, properties and applications of the bionanosystems, with an emphasis on the therapeutic and imaging fields.
2. Demonstrate an integrated view of the bionanosystems, including the different types, production and encapsulation methods, functionalization routes, characterization methodologies, biochemical barriers and translation challenges.
3. Demonstrate the ability to interconnect the acquired theoretical and practical knowledge to solve specific problems related to nanosystems applied to therapeutic and imaging fields.
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Syllabus |
Theoretical component:
T1. Historical perspective of bionanosystems (nanosystems applied to biochemistry/biomedicine in the therapeutic and imaging areas)
T2. Properties of bionanosystems
T3. Organic, inorganic and hybrid nanosystems
T4. Encapsulation of bioactive molecules in bionanosystems
T5. Biochemical barriers to be overcome by the bionanosystems
T6. Covalent and non-covalent functionalization of bionanosystems
T7. Methodologies for the physicochemical and biological characterization of bionanosystems
T8. Bionanosystems in the treatment and imaging of human diseases
T9. Clinical application of bionanosystems
T10. Challenges in bionanosystems translation and nanotoxicology
Practical component:
P1. Preparation of organic bionanosystems
P2. Synthesis of inorganic bionanosystems
P3. Functionalization and encapsulation of molecules in the bionanosystems
P4. Physicochemical characterization of bionanosystems
P5. Biological characterization of bionanosystems
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Main Bibliography |
• Natelson D. (2015). Nanostructures and nanotechnology. Cambridge: Cambridge University. ISBN 978-0-521-87700-8
• Jelinek R. (2015). Nanoparticles. Berlin: Walter de Gruyter. ISBN 978-3-11-033002-1
• Vander A. J., Sherman J. H. & Luciano D. S. (2001). Human physiology. Boston: McGraw-Hill. ISBN 0071180885
• Weinberg R. A. (2007). The biology of cancer. New York: Garland Science. ISBN 0815340761
• Scientific articles published in international peer-reviewed journals (indexed to ISI Web of Knowledge, Web of Science and Scopus)
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Teaching Methodologies and Assessment Criteria |
N.A.
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Language |
Portuguese. Tutorial support is available in English.
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