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Learning outcomes |
The Bioactive Compound Development course aims to provide current knowledge on the molecular basis of the discovery, design, development, and action of bioactive compounds, focusing on molecules of interest to human medicine, more specifically:
- To understand the essential physicochemical and structural bases for the rational design and comprehension of the molecular mechanisms of action of active principles;
- To understand current methods and strategies for the discovery and development of prototypes;
- To know how to relate the chemical characteristics of bioactive compounds to their bioavailability and pharmacokinetics;
- To know, interpret, and predict structure-activity relationships in a rational and mechanistic way;
- To know and predict interactions of bioactive compounds with the main biological targets and the underlying molecular mechanisms.
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Main Bibliography |
1. G. L. Patrick, An Introduction to Drug Synthesis, Oxford University Press, 2015;
2. R. B. Silverman, The Organic Chemistry of Drug Design and Drug Action, 2nd Ed., Elsevier Academic Press, 2004;
3. G. L. Patrick, An Introduction to Medicinal Chemistry, 6th Ed., Oxford University Press, 2017;
4. C. Avendaño, Introductión a la Química Farmacéutica, 2ª Ed., Mc.Graw-Hill, 2001;
5. T. Nogrady, D. F. Weaver, Medicinal Chemistry – A Molecular and Biochemical Approach, 3rd Ed., Oxford University Press, 2005;
6. A. Delgado, C. Minguillón, J. Joglar, Introductión a la Química Terapéutica, 2ª Ed., Diaz de Santos, 2003;
7. C. Dickson, Medicinal Chemistry Laboratory Manual, CRC Press: Boca Raton, London, New York, Washington DC, 1999;
8. http://old.iupac.org/publications/cd/medicinal_chemistry/
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