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Clinical Biochemistry

Clinical Biochemistry

Code	8378
Year	3
Semester	S1
ECTS Credits	6
Workload	PL(30H)/T(30H)
Scientific area	Biomedical Sciences
Mode of delivery	Face-to-face.
Work placements	Not applicable.
Learning outcomes	Rationally develop the natural abilities of the student. The lectures are integrated with practical and/or theoretical-practical classes in order to become participatory classes and allowing to transmit the knowledge in an integrated and non-dispersible form, where students build and correlate different facts by discussing issues and practical problems. This course, in which the principles of Biochemistry and Physiology are applied to the understanding of human disease, requires the use of acquired knowledge and was taught in past course units, reinforcing their use. The fundamental objectives of Clinical Biochemistry should include: • Apply knowledge of basic biochemistry in understanding the disease and problem solving; • Acquire knowledge about the biochemical changes in disease; • Acquaint the student with the biochemical parameters most commonly determined in the Clinical Chemistry laboratory routine.
Syllabus	Theory 1. Clinical Biochemistry concept 2. Clinical Chemistry and Quality Analyses 2.1. Types of analyses and biological samples 2.2. Errors. Importance of Quality Control at different stages of the laboratory 3. Biological fluids (BF) 3.1. Differences in chemical composition 3.2. Special extravascular BF 4. Laboratory parameters and biochemical mechanisms involved in the diagnosis of changes: 4.1. Renal function 4.2. Fluid electrolyte and acid-base balance 4.3. Carbohydrates Metabolism 4.4. Lipid Metabolism 4.5. Hepatic function 4.6. Proteins and Enzymes Practice Glucose assay Cholesterol, triglycerides and HDL-c assay Plasma/urine protein assay. Proteins and lipoproteins electrophoresis interpretation Urea, uric acid and creatinine assay Total bilirubin assay and alkaline phosphatase. Analysis of type II urine and microscopic observation of urinary sediment
Main Bibliography	Clinical Chemistry: Theory, Analysis, Correlation, Lawrence A. Kaplan, Amadeo J. Pesce and Steven C. Kazmierczak, Eds. Mosby Inc., St. Louis (Elsevier) (2010). Textbook of Biochemistry, with Clinical Correlations (7th edition), Thomas M. Devlin, Ed. John Wiley and Sons, Ltd. New York (2011). Clinical Chemistry. Principles, Thechniques, Correlations (7th edition), Michael L. Bishop, Edward P. Fody and Larry Schoeff. Baltimore, MD: Lippincott Williams & Wilkins (2013). Clinical Biochemistry. An illustrated colour text (5th editino). Allan Gaw, Michael J. Murphy, Robert A. Cowan, Denis S.T., J. O’Reilly, Michael J. Stewart, James Shepherd, Editora Churchill Livingstone, Elsevier 2013. Henry''s Clinical Diagnosis and Management by Laboratory Methods, 22ª Edição, McPherson and Pincus, Eds. Elsevier Saunders (2011) Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics (7th Edition). Burtis, C. and Bruns, D.E., Eds. Elsevier Saunders (2015)
Language	Portuguese. Tutorial support is available in English.