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Clinical Immunology

Code 8439
Year 1
Semester S1
ECTS Credits 6
Workload TP(60H)
Scientific area Biochemistry
Entry requirements N/A
Mode of delivery Face-to-face
Work placements Not applicable.
Learning outcomes (1) To analyse the most relevant aspects of the structure, dynamics and functions of the immune system in humans.
(2) To stimulate critical thinking about research in Clinical Immunology.
(3) To acknowledge the progress and limitations of Clinical Immunology.

At the end of this curricular unit, the students should be capable of:
(1) Integrating and applying knowledge from basic immunopathology in the field of Clinical Immunology.
(2) Applying the principles of clinical and laboratory diagnosis of immunologically mediated diseases.
(3) Analysing the basic principles of therapeutic intervention in the Clinical Immunology.
(4) Performing critical analysis of research studies in Clinical Immunology.
(5) Creating research projects in Clinical Immunology.
Syllabus 1. REVIEW OF BASIC CONCEPTS IN IMMUNOLOGY
2. HYPERSENSITIVITY REACTIONS. Immunopathology. Laboratory diagnosis.
3. TOLERANCE, AUTOIMMUNITY AND AUTOIMMUNE DISEASES. Autoimmunity and autoimmune disease. Autoimmune diseases: general and immunopathological aspects, diagnostic tests.
4. ATOPIC ALLERGIC DISEASES. Immunopathology: Th2 cells, eosinophils, B lymphocytes, mast cells. Diagnostic tests: in vivo (skin prick tests) and in vitro (specific IgE). Immunotherapy and corticotherapy.
5. ANTI-TUMOR IMMUNITY. Immune response to tumors (dendritic cells, CD4+ T cells, CD8+ T cells, NK cells, B lymphocytes). Escape mechanisms from antitumor immunosurveillance. Immunological treatment of tumors.
6. ANTI-INFECTIOUS IMMUNITY. Antibacterial, anti-viral and antiparasitic immunity. Escape mechanisms from anti-infectious immunosurveillance. Vaccination.
7. PRIMARY IMMUNE DEFICIENCIES (PID). B and T cell deficiencies. Deficiencies of the innate immune system. Diagnosis and treatment of PID.
Main Bibliography 1. Cellular and Molecular Immunology, 9th Edition (2018) Abbas AK, Lichtman HH, Pillai S, (Eds), Elsevier
2. Kuby Immunology, 8th Edition (2019) Kindt TJ, Osborne BA, Goldsby RA, (Eds), W.H. Freeman.
3. Immunology at a Glance, 10th Edition (2013) Playfair JHL, Chain BM, (Eds.), Wiley-Blackwell
4. Essentials of Clinical Immunology, 6th Edition (2014) Chapel H, Haeney M, Misbah S, Snowden N, (Eds.), Wiley-Blackwell
5. Fundamentos de Imunologia, 2ª Edição (2012) Arosa FA, Cardoso EM, Pacheco FC, (Eds), LIDEL, Edições Técnicas
Teaching Methodologies and Assessment Criteria Classical lectures, flipped classroom lectures and Interactive seminars. Presentation and discussion of
research project proposals developed by the students.

Evaluation
1) Theoretical Assessment (TA) - 2 Partial Written Tests or Final Theoretical Exam (FTA). A minimum of 9.5 pts are needed to pass TA.
2) Theoretical - Practical Assessment (TPA) - 2 components a) Continuous Assessment (CA) - Participation in discussions (50% of TPA mark) b) Presentation of research project (PRP)- (50% of TPA mark).
Final Mark = TA x 0.6 + TPA (CA x 0.5 + PRP x 0.5) x 0.4
Minimum attendance 75%

Evaluation
1) Theoretical Assessment (TA) - 2 Partial Written Tests or Final Theoretical Exam (FTA). A minimum of 9.5 pts are needed to pass TA.
2) Theoretical - Practical Assessment (TPA) - Presentation of research project (PRP)
Final Mark = TA x 0.6 + PRP x 0.4
Language Portuguese. Tutorial support is available in English.
Last updated on: 2021-10-13

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