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Clinical Immunology

Code 8439
Year 1
Semester S1
ECTS Credits 6
Workload TP(60H)
Scientific area Biochemistry
Entry requirements Not applicable.
Mode of delivery Face-to-face
Work placements Not applicable
Learning outcomes (1) To analyse the most relevant aspects of the structure, dynamics and functions of the immune system in humans.
(2) To stimulate critical thinking about research in Clinical Immunology.
(3) To analyze the implementation tools of scientific studies in Clinical Immunology;
(4) To recognize the advances and limitations of Clinical Immunology in immunopathology and immunomodulation of various pathologies in humans.
At the end of this curricular unit, the students should be capable of:
(1) Integrating and applying knowledge from basic immunopathology in the field of Clinical Immunology.
(2) Applying the principles of clinical and laboratory diagnosis of immunologically mediated diseases.
(3) Analysing the basic principles of therapeutic intervention in the Clinical Immunology.
(4) Performing critical analysis of research studies in Clinical Immunology.
(5) Creating research projects in Clinical Immunology.
Syllabus 1. HYPERSENSITIVITY REACTIONS
Classification (types I, II, III and IV). Laboratory diagnosis.
2. TOLERANCE AND AUTOIMMUNITY
General concepts of immune tolerance. Autoimmunity and autoimmune disease. Autoimmune diseases: general aspects, immunopathological aspects, diagnostic tests.
3. ATOPIC ALLERGIC DISEASES
General aspects. Immunopathology: Th2 cells, eosinophils, B lynphocytes, mast cells. Diagnostic tests: in vivo (skin prick tests) and in vitro (specific IgE). Immunotherapy and corticotherapy.
4. ANTI-TUMOR IMMUNITY
General concepts of oncobiology. Immune response to tumors (dendritic, CD4+ T, CD8+ T and NK cells, B lymphocytes).
Escape mechanisms from anti-tumor immunovigilance. Immunological treatment of tumors.
5. ANTI-INFECTIOUS IMMUNITY
General aspects. Anti-bacterial, anti-viral and anti-parasitic immunity. Escape mechanisms from anti-infectious immunovigilance. Vaccination.
6. PRIMARY IMMUNE DEFICIENCIES

Main Bibliography “Fundamentos de Imunologia” (2ª Edição; 2012); Arosa, Cardoso & Pacheco (eds.); LIDEL; ISBN: 978-972-757-856-6 Adicional “Cellular and Molecular Immunology” (8ª Edição; 2014); Abbas AK, Lichtman HH (Eds); Saunders; ISBN-10: 0323222757; ISBN-13: 978-0323222754
Teaching Methodologies and Assessment Criteria Lectures and Interactive seminars.
Presentation and discussion of research project proposals developed by the students.

TEACHING-LEARNING
Final Mark = Theoretical Assessment (AT - average of 2 intermediate tests) x 0.6 + Continuous Assessment (AC) (AP = participation in classes x 0.5 + API = presentation of research project proposal x 0.5) x 0.4

For worker-students
Final Mark = Theoretical Assessment (AT - average of 2 intermediate tests) x 0.6 + API = presentation of research project proposal x 0.4

FINAL EXAM
Final Grade = Theoretical Assessment (AT - Exam) x 0,6 + Continuous Assessment (AC) x 0.4
Continuous Assessment (CA) is calculated as follows:
     - participation in classes (PA) x 0.5 + presentation of research project proposal (API) x 0.5

For worker-students
Final Mark = Theoretical Assessment (AT - Exam) x 0.6 + API = presentation of research project proposal x 0.4
Language Portuguese. Tutorial support is available in English.
Last updated on: 2020-01-17

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