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  4. Neurobiologia


Code 8443
Year 1
Semester S2
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Biochemistry
Entry requirements None
Mode of delivery Class attendance is mandatory
Learning outcomes To provide knowledge about: Function of the constituent cells of the nervous system and on the mechanisms of neuronal communication. Experimental methods used in neurosciences. Provide basic concepts about neuroanatomy and about the plasticity of the nervous system. Concepts: To know the cellular constitution of the nervous tissue and the forms of communication between the cells that constitute the nervous system. Integrate knowledge about the basic mechanisms of functioning of the nervous system. To relate the alterations associated to some pathologies of the nervous system with the basic neuronal mechanisms. Skills: Understand the fundamentals of different laboratory techniques and be able to develop an experimental protocol. Know how to analyze a scientific article. Know how to synthesize information and transmit it clearly and accurately to colleagues. Know how to structure information in the form of a scientific article.
Syllabus 1. Biology of neuronal cells 2. Synaptic transmission. Axonal transport 3. Neuronal metabolism 4. Microglia and neuroinflammation 5. Mechanisms of neurotransmission: types of neurotransmitters; synthesis and storage; axonal transport, characteristics of the release and termination of the action. 6. Dopamine 7. Serotonin 8. Acetylcholine 9. Neuropeptides 10. Glutamate, Aspartate, GABA and Glycine 11. Purines and Endocannabinoids Practical activities: Development of experimental protocols with models used in neurosciences.
Main Bibliography Required reading: Neuroscience. Dale Purves, George J. Augustine, David Fitzpatrick , William C. Hall, Anthony-Samuel Lamantia, James O. McNamara , S. Mark Williams. Sinauer Associates; 5rd edition (2012). Neurobiology: Molecules, Cells and Systems. Gary G. Matthews. Blackwell Publishers; 2nd edition (2001). Basic Neurochemistry, 8th Edition : Molecular, Cellular and Medical Aspects. George J. Siegel, R. Wayne Albers, Scott Brady, Donald L. Price. Academic Press; edition (2011).
Teaching Methodologies and Assessment Criteria Teaching Methodologies - Online lectures. - Videos on methodologies that were expected to be used in the laboratory component. - Discussion of laboratory methodologies through surveys (open questions). - Participation in online sessions is encouraged through weekly mini-tests on basic aspects of the subject. - Two online assessments, via Moodle.
Language Portuguese. Tutorial support is available in English.
Last updated on: 2020-05-11

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