Neurobiology

Code	8443
Year	1
Semester	S2
ECTS Credits	6
Workload	PL(30H)/T(30H)
Scientific area	Biochemistry
Entry requirements	None
Mode of delivery	Class attendance is mandatory
Learning outcomes	Provide knowledge on: The function of the constituent cells of the nervous system and on the mechanisms of neuronal communication. Experimental methods used in neuroscience. Provide basic concepts on neuroanatomy and the plasticity of the nervous system. Concepts: To know the cellular constitution of the nervous tissue and the forms of communication between the cells that constitute the nervous system. Integrate knowledge about the basic mechanisms of functioning of the nervous system. Relate the changes associated with some pathologies of the nervous system with the basic neuronal mechanisms. Skills: Understand the fundamentals of different laboratory techniques and be able to develop an experimental protocol. Know how to analyze a scientific article. Know how to synthesize information and transmit it clearly and accurately to colleagues.
Syllabus	1. Biology of neuronal cells 2. Neurogenesis 3. Synaptic transmission. Axonal transport 4. Neuronal metabolism 5. Microglia and neuroinflammation 6. Neurotransmission mechanisms: types of neurotransmitters; synthesis and storage; axonal transport, characteristics of release and termination of action. 7. Dopamine 8. Serotonin 9. Glutamate, Aspartate, GABA and Glycine 10. Purines and Endocannabinoids Practical activities: Development of experimental protocols with models used in neurosciences.
Main Bibliography	Purves, D., et al. (2018) Neuroscience. 6th Edition, Sinauer Associates, New York. George J. Siegel, R. Wayne Albers, Scott Brady, Donald L. Price. Basic Neurochemistry, Molecular, Cellular and Medical Aspects. Academic Press. Rego, AC., Duarte, CB and Oliveira, CR. (2017). Neurociências. Lidel
Language	Portuguese. Tutorial support is available in English.