| Code |
8443
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| Year |
1
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| Semester |
S2
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| ECTS Credits |
6
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| Workload |
PL(30H)/T(30H)
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| Scientific area |
Biochemistry
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|
Entry requirements |
None
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Mode of delivery |
Class attendance is mandatory
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Learning outcomes |
Provide knowledge on:
The function of the constituent cells of the nervous system and on the mechanisms of neuronal communication.
Experimental methods used in neuroscience.
Provide basic concepts on neuroanatomy and the plasticity of the nervous system.
Concepts:
To know the cellular constitution of the nervous tissue and the forms of communication between the cells that constitute the nervous system.
Integrate knowledge about the basic mechanisms of functioning of the nervous system.
Relate the changes associated with some pathologies of the nervous system with the basic neuronal mechanisms.
Skills:
Understand the fundamentals of different laboratory techniques and be able to develop an experimental protocol.
Know how to analyze a scientific article.
Know how to synthesize information and transmit it clearly and accurately to colleagues.
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Syllabus |
A- Biology of neural cells
Neurons
Synaptic transmission
Axonal transport
Synaptic plasticity and memory storage
Neuronal and glial metabolism
Glial cells
Diverse functions of microglia and astrocytes - GB
Neuroinflammation - GB
Glymphatic system - GB
Circadian changes in nervous system cells - TQ
B- Neurotransmission
Types of neurotransmitters; synthesis and storage; characteristics of release and termination of action. Alterations to neurotransmission in pathologies of the nervous system
Amines (dopamine, noradrenaline, serotonin)
Acetylcholine
Glutamate & GABA
Neuropeptides
Practical activities: Development of experimental protocols with models used in neuroscience.
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Main Bibliography |
Purves, D., et al. (2018) Neuroscience. 6th Edition, Sinauer Associates, New York.
George J. Siegel, R. Wayne Albers, Scott Brady, Donald L. Price. Basic Neurochemistry, Molecular, Cellular and Medical Aspects. Academic Press.
Rego, AC., Duarte, CB and Oliveira, CR. (2017). Neurociências. Lidel
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Teaching Methodologies and Assessment Criteria |
Lectures
Discussion of scientific papers
Analysis of experimental data
Laboratory activities
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Language |
Portuguese. Tutorial support is available in English.
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