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Organic Chemistry

Code 8634
Year 2
Semester S1
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Chemistry
Entry requirements Not applicable.
Mode of delivery Face-to-face with recourse to e-learning
Work placements Not applicable.
Learning outcomes This course unit aims to teach the basic knowledge to classify the main types of reactions in organic chemistry and its understanding through its mechanism. At the end of the course unit the student should be able to combine the basic knowledge learned in the course unit with an adequate bibliographic support, in order to predict and classify the chemical behavior of compounds belonging to the main functional groups. It aims also to encourage literature research and reading habits, thus stimulating self-learning in order to solve the proposed problems and to develop a seminar about a theme related with both pharmaceutical sciences and organic chemistry
Syllabus 1 Reactions in Organic Chemistry
1.1 Main types
1.2 Reaction mechanisms and the use of curved arrows utilization to their illustration.
2 Saturated carbons
2.1 Nucleophilic substitution reactions
2.2 Elimination reactions
2.3 Radical reactions
3 Unsaturated carbons
3.1 Electrophilic addition
3.2 Conjugated systems
3.3 Alkenes formation
4 Carbonyl group
4.1 Nucleophilic addition
4.2 Conjugate addition
4.3 Substitution
5 Oxidation-reduction reactions
6 Enols and Enolates: reactions and formation

Practical classes:
- Indolin-2,3-dione reduction with NaBH4 and NH2NH2 (Wolff- Kishner reduction) – A practical example of microwaves in organic synthesis (2 classes)
- Arrows in Organic Chemistry. Introduction to reaction mechanisms
- Saturated Carbons
- Unsaturated Carbons
- Carbonyl Group
- Oxidation Reduction + Enols and enolates
Main Bibliography - T. W. G. Solomons, C. B. Fryle, Química Orgânica, Vol. 1 e 2, 10ª ed., LTC Livros Técnicos e Científicos Editora S. A.: Rio de Janeiro, 2012.
2. Recommended reading:
- M. M. M. Pinto, Manual de Trabalhos Laboratoriais de Química Orgânica e Farmacêutica,Lidel – edições técnicas lda: Lisboa, 2011.
- M. B. Smith, J. March, March’s Advanced Organic Chemistry – Reactions, Mechanisms and Structure, 7th ed., John Wiley & Sons: New York, 2013.
- F.A. Carey, R.J. Sundberg, Advanced Organic Chemistry Part A: Structure and Mechanisms, 5th ed,Springer, New York, 2007.
Language Portuguese. Tutorial support is available in English.
Last updated on: 2023-01-23

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