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Biochemical Processes of Hematopoiesis

Code 8867
Year 1
Semester S2
ECTS Credits 6
Workload PL(30H)/T(30H)
Scientific area Biochemistry
Entry requirements N/A
Mode of delivery face to face
Work placements Non aplicable
Learning outcomes The main objective of this course unit is to expand the students’ knowledge in relation to blood cells, integrating theoretical concepts, experimental approaches and clinical cases.
At the end of this course unit, students should be able to:
1. Describe the mechanisms and factors that regulate hematopoiesis
2. Describe the main stages of normal hematopoiesis of blood cells
3. Acquire the basic skills to work in an experimental laboratory of Hematology
4. Describe the biological processes that lead to the abnormal development of blood cell populations
5. Describe the major pathologies associates with defects in hematopoiesis
6. Integrate knowledge and skills in solving problems
Syllabus 1. Blood and general Hematopoiesis
2. Thrombopoiesis, Hemostasis and Coagulation Disorders
3. Erythropoiesis, anemia and oher disorders of the erythorcyte
4. Granulopoiesis, Monopoiesis and benign changes in these lineages
5. Lymphopoiesis and main pathologies associated to benign and malignant processes
6. Blood transfusion and transplantation
7. Basic concepts in an hematology laboratory
8. Laboratory methods and techniques applied to the study of hematopoiesis
Main Bibliography 1. Required reading
a. Essential Haematology – Hoffbrand A.V., Moss, P.A.H. & Pettit J.E. eds, 5th ed., Blackwell Publishng
b. Color Atlas of Hematology – Theml H., Diem H. & Haferlach eds, 2nd ed., Thieme
c. Textbook of Medical Physiology – Guyton & Hall, 11th ed., Sauders

2. Recommended reading
a. Textbook of Biochemistry with clinical correlations – Thomas M. Devlin, 5th ed., Wiley-Liss
Teaching Methodologies and Assessment Criteria The student acquires the proposed skills through theoretical classes and practical theoretical classes by videoconference, of a dynamic nature in order to interact both in the interpretation of contents, resolution of practical cases, as well as the entire process of interpreting laboratory results. apply appropriate photographs will be shown especially with regard to microscopic observations.


Classification 70% Theoretical (T), and 30% Theoretical-Practical (TP). The TP evaluation, includes the realization of works carried out during the TP classes, proposed for evaluation (10%) and the elaboration and discussion of a monograph on the theme. previously selected and / or presentation and discussion of a scientific article. (20%). The minimum grade for approval is 9.5 values. The criterion for admission to the final exam, consists of having previous approval in the TP assessment, of 9, 5 values.
Language Portuguese. Tutorial support is available in English.
Last updated on: 2020-05-14

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