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Biochemical Processes of Hematopoiesis

Biochemical Processes of Hematopoiesis

Code	8867
Year	1
Semester	S2
ECTS Credits	6
Workload	PL(30H)/T(30H)
Scientific area	Biochemistry
Entry requirements	N/A
Mode of delivery	face to face
Work placements	Non aplicable
Learning outcomes	This Curricular Unit aims to deepen students' knowledge of the cells that make up blood, integrating theoretical concepts and experimental and clinical case approaches. At the end of this Course Unit the student should be able to: 1. Describe and relate biochemical aspects in the Hematopoiesis process. 2. Identify the main changes that may occur in the hematopoiesis process. 3. Describe the main stages of normal blood cell hematopoiesis. 4. Acquire the basic skills to work in an experimental laboratory within the scope of Hematology. 5. Describe the biological processes that lead to the abnormal development of blood cell populations. 6. Correlate to changes that occur in hematopoiesis with different clinical situations. 7. Integrate theoretical and practical knowledge in solving type problems - discussion of clinical cases.
Syllabus	1. Blood and General Hematopoiesis - different types of anemias and their pathophysiological characteristics and associated biochemical aspects 2. Hemoglobin synthesis 3. Thrombopoiesis. 4. Phases of hematopoiesis / erythropoiesis. 5. Granulopoiesis, Monopoiesis and benign changes in these strains. 6. Lymphopoiesis - monopoiesis and benign and malignant changes of the various lineages. 7. leukemias and lymphomas 8. Hemostasis process: coagulation and fibrinolysis. 9. Transplantation and blood transfusion. 10. Basic laboratory concepts in Hematology. 11. Laboratory methods and techniques applied to the study of Hematopoiesis.
Main Bibliography	1. Required reading a. Essential Haematology – Hoffbrand A.V., Moss, P.A.H. & Pettit J.E. eds, 5th ed., Blackwell Publishng b. Color Atlas of Hematology – Theml H., Diem H. & Haferlach eds, 2nd ed., Thieme c. Textbook of Medical Physiology – Guyton & Hall, 11th ed., Sauders 2. Recommended reading a. Textbook of Biochemistry with clinical correlations – Thomas M. Devlin, 5th ed., Wiley-Liss b. Slides used and available by teachers
Language	Portuguese. Tutorial support is available in English.