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Medicinal Chemistry
Laboratorial Techniques in Chemistry

Laboratorial Techniques in Chemistry

Code	10239
Year	1
Semester	S1
ECTS Credits	8
Workload	PL(60H)/TP(30H)
Scientific area	Química Medicinal
Entry requirements	-
Learning outcomes	This curricular unit (CU) aims to teach the basic knowledge for a good practice in a chemistry lab, as well the registration and subsequent treatment of the results obtained. Recognize the physical, chemical and toxic characteristics of reagents and solvents; Use correctly scales, volumetric material and specific equipment used in unit operations in chemistry. Select glassware and laboratory equipment in accordance with the application. Apply good laboratory practices in the preparation of solutions. Register and organize data and experimental observations. Identify the objectives of the proposed experiments and the experimental methods to achieve them. Plan and execute the experiments in question, including observation, measurement and registration of experimental data.
Syllabus	1. introduction to the laboratory: - Basic rules of safety and conduct in a chemistry laboratory - Reagents and solvents - physical, chemical and toxicity characteristics - Material and equipment commonly used in the laboratory - Waste management in the laboratory 2. Laboratory work methodology - Laboratory notebook - Work preparation - Recording and presenting observations and measurements - Processing results - Preparation and presentation of reports 3. Solutions - Concentrations - Calculating and preparing solutions - Dilutions 4. Introduction to volumetry - acid-base titrations 5. Distillation 6. Extraction 7. Recrystallization 8. Chromatography
Main Bibliography	-D.A. Skoog, D.M. West, F.J. Holler, S.R. Crouch, "Fundamentals of Analytical Chemistry", Saunders College Publishing, EUA, 10th Ed, 2021. - J.A.M. Simões, M.A.B. Castanho, I.M.S. Lampreia, F.J.V. Santos, C.N. Castro, M.T. Pamplona, M.E.M. Piedade, “Guia do Laboratório de Química e Bioquímica”, Lidel, Lisboa, 2017 - J.R. Mohrig, C.N. Hammond, T.C. Morrill, D.C. Nerckers, “Experimental Organic Chemistry” W.H. Freeman and Company”, New York, 1997 - J.M. Postma, J.L. Roberts Jr., J.L. Hollenberg, “Chemistry in the Laboratory”, 5th ed., W:H: Freeman & Co., New York, 2000. - R. Chang,K. Goldsby “Química”, 11ª ed., McGraw-Hill, Lisboa, 2013. - A.J.L. Pombeiro, “Técnicas e Operações Unitárias em Química Laboratorial”, 3ª ed., Fundação Calouste Gulbenkian, Lisboa, 1998. - J. Mendham, R.C. Denney, J.D. Barnes, M. Thomas, ”Vogel’s Análise Química Quantitativa”, 6ª ed., LTC Editora, Rio de Janeiro, 2002.
Language	Portuguese. Tutorial support is available in English.