Learning outcomes |
The main objective is to study the structural and conformational characteristics of proteins and their biological function. It is also intended to relate conformational changes with certain diseases through examples of proteins that perform diverse biological functions. At the end of this course students should be able to: -Identify and describe the fundamental principles that define the structure and conformation of proteins and the mechanisms that control in vitro and in vivo protein folding; -Describe the relation between the onset of neurodegenerative diseases with protein conformational changes; -Explain the cellular strategies for protein quality control; -Apply different methods for crystalization and analysis of proteins (X-ray diffraction, circular dichroism, IR spectroscopy, fluorescence, nuclear magnetic resonance, surface plasmon resonance); -Demonstrate capacity for critical analysis and presentation of scientific papers.
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Main Bibliography |
1. Required reading -Kessel, A., Ben-Tal, N (2018) “Introduction to Proteins: Structure, Function, and Motion” 2nd Edition, CRC Press, Taylor and Francis Group, (ISBN 978-1-4987-4717-2) -Petsko, G. & Ringe, D. (2017) "Protein Structure and Function", Primers in Biology, Oxford University Press (ISBN13 9780878936632) -Xiong, J (2012) Essential Bioinformatics, Cambridge University Press (ISBN: 9780511806087) -Whitford, D. (2005) "Proteins: Structure and Function", Wiley (ISBN: 978-0-471-49894-0) - Young, D. (2009) Computational drug design: a guide for computational and medicinal chemists, John Wiley & Sons, Ltd. (ISBN: 978-0-470-12 -Selected papers
2. Recommended reading -Muñoz, V (2008) Protein Folding, Misfolding and Aggregation, RSC Biomolecular Siciences (ISBN 978-1-84755-828-2) - Patrick, G.L. (2010) An Introduction to Medicinal Chemistry, 4th Ed., Oxford University Press. ISBN: 9780198749691
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