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Biochemistry II

Code 12817
Year 2
Semester S2
ECTS Credits 6
Workload PL(15H)/T(30H)/TP(15H)
Scientific area Biochemistry
Entry requirements Not applicable.
Mode of delivery Face to face.
Work placements Not applicable.
Learning outcomes The unit of Biochemistry II aims to develop and apply the knowledge, attitudes and skills acquired in Biochemistry I, in understanding the biochemical meaning of metabolic strategies and its regulation.
At the end of this course the student should be able to:
-Describe and to explain the bioenergetic aspects related to oxidative phosphorylation, the substrate-level phosphorylation and the metabolism of the main nutritional components of living beings;
-Identify, to describe and to interpret the metabolic pathways of carbohydrates, lipids, amino acids and nucleotides;
-Compare the role of different hormones in the energy metabolism and to interpret the mechanism of hormonal regulation;
-Explain the integration of metabolic pathways and its regulation;
-Perform experimental techniques in the field of Biochemistry and to analyze and interpret the results accurately and critically;
Syllabus 1. Metabolism and Bioenergetics. Oxidation-reduction reactions in biological systems.
2. Carbohydrate metabolism. Glycolysis. Regulation. Glycogen metabolism. Gluconeogenesis. Precursors and Regulation. Pentose phosphate pathway.
3. Citric acid cycle. Regulation.
4. Oxidative phosphorylation. Electron transport chain. Regulatory phosphorylation
5 . Lipid metabolism. ß-oxidation of fatty acids. Metabolism of ketone bodies. Synthesis of lipids. Cholesterol and lipoproteins metabolism
6. Metabolism of amino acids. Urea cycle.
7. Metabolism of nucleic acids
8. Hormonal regulation and integration of mammalian metabolism
9. Experimental: Hydrolysis of compounds containing phosphate groups. Production of pyruvate and acetaldehyde during fermentation of glucose by yeast. Mitochondrial respiration. Amino acid metabolism: determination of alanine transaminase activity.
Main Bibliography - D.L. Nelson e M.M. Cox (2021) Lehninger Principles of Biochemistry: International Edition, 8th ed., W.H.Freeman & Co Ltd.
- J.M. Berg, J.L. Tymoczko, L. Stryer (2015) Biochemistry. 8th ed., New York: Freeman
Complementar
- A.Quintas, A.P Freire, M.J. Halpern, (2008) Bioquímica - Organização Molecular da Vida, Ed.Lidel
- D. Voet, J.G. Voet (2010). Biochemistry. 4th ed., New York: John Wiley & Sons
Teaching Methodologies and Assessment Criteria The students will acquire the skills proposed for this course in lectures of dynamic character, and when appropriate, tutorials based on educational goals and problem-based learning. Laboratorial lectures involve experimental work of theoretical concepts, in which students apply their knowledge in the execution of experimental techniques, as well as in data analysis, interpretation of results and solving problems.

Final Assessment (FA): 70% Theoretical (T) + 30% Practical (P)

T assessment includes: T1 (30%) + T2 (30%) + T3 (30%) + Minitests at final of T classes (10%)
The P assessment includes 1 TP test
A minimum of 9.5 pts is needed to pass in T and in P.
For attendance or admission to exam: minimum 9.5 in P (no minimum for T)
The exam evaluates the T and corresponds to 70% of the grade.
Language Portuguese. Tutorial support is available in English.
Last updated on: 2024-06-14

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