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Clinical Biochemistry

Clinical Biochemistry

Code	12873
Year	1
Semester	S1
ECTS Credits	6
Workload	PL(30H)/T(30H)
Scientific area	Bioengenharia
Mode of delivery	Face-to-face
Work placements	N/A
Learning outcomes	Give students theoretical and practical training in the field of Clinical Chemistry Prepare students for execution of a clinical and laboratorial study, as well as a correct interpretation of analytical results in different contexts Develop student's accuracy of reasoning and demand of knowledge -Know to apply the skills of basic biochemistry in the understanding of the disease -Familiarize with the biochemical and analytical parameters most commonly quantified in a laboratory -Know how to perform laboratory techniques -Working as a team and have a critical sense of their errors -Be able to apply theoretical knowledge to the laboratory work and to the interpretation of results -Understand the importance of Quality Controls -Recognize clinical and laboratory situations associated to changes with different functions and physiologic and pathophysiologic systems -Be able to interpret all the parameters analyzed in a laboratory of Clinical Chemistry
Syllabus	Theoretical 1. Concept of Clinical Biochemistry 2. Analyses in Clinical Chemistry and Quality 2.1 Types of analysis and biological samples 2.2 Analytical errors. Importance of Quality Control in different laboratory stages 3. Biological fluids(BF) 3.1 Differences in chemical composition 3.2 Special Extravascular BF 4. Biochemical mechanisms and Laboratory parameters involved in the diagnosis of changes in: 4.1 Renal Function 4.2 Fluid and Electrolyte balance and acid-base 4.3 Carbohydrate Metabolism 4.4 Lipid Metabolism 4.5 Liver Function 4.6 Proteins/Enzymes Practical Glucose assay Cholesterol, triglycerides and HDL-c assay Plasma/urine protein assay. Proteins and lipoproteins electrophoresis interpretation Urea, uric acid and creatinine assay Total bilirubin assay and alkaline phosphatase. Analysis of type II urine and microscopic observation of urinary sediment
Main Bibliography	• Clinical Chemistry: Theory, Analysis, Correlation (4th edition), Lawrence A. Kaplan, Amadeo J . Pesce and Steven C. Kazmierczak Eds., Mosby-Year Book, Inc., St. Louis (2003). • Textbook of Biochemistry, with Clinical Correlations (6th edition), Thomas M . Devlin, Ed. , John Wiley and Sons, Ltd. New York (2006). • Clinical Chemistry. Principles, Procedures, Correlations (5th edition), Michael L. Bishop, Edward P. Fody and Larry Schoeff. Baltimore, M D: Lippincott Wi l l iams & Wi lkins (2005). • Clinical Biochemistry (4th edition). Allan Gaw, Michael J. Murphy, Robert A. Cowan, Denis S.T., J .O’Reilly, Michael J . Stewart, James Shepherd, Editora Churchill Livingstone, 2008. • Henry's Clinical Diagnosis and Management by Laboratory Methods (21th edition), Richard A. McPherson, Matthew R. Pincus, Elsevier, 2006.
Language	Portuguese. Tutorial support is available in English.