| Code |
13526
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| Year |
1
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| Semester |
S2
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| ECTS Credits |
6
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| Workload |
TP(60H)
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| Scientific area |
Biomedical Sciences
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Entry requirements |
To have basic knowledge about Human Physiology.
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Mode of delivery |
Face-to-face
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Work placements |
does not apply
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Learning outcomes |
Main goals: This course unit enables students to have the main building blocks that allow a correct understanding of the concept of bioavailability, the factors that depends of their determination and implication on the therapeutic efficacy of the drugs.
The student will be able to:
- understand the basic parameters of Pharmacology and to recognize the general factors that contribute to the drugs bioavailability
- Identify and analyze the protocols and results of bioequivalence assays
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Syllabus |
I – Introduction to Pharmacology
II - Influence of absorption, distribution, metabolism and Excretion on drugs bioavailability
III – Genetic and non-genetic factors that influence the Inter individual Variability of drugs response
IV – Relationship between the chemical characteristics and drugs bioavailability
PL: Influence of the pH of the medium and the pKa of drugs on their absorption/crossing of membranes - Laboratory study of the influence of pH on the absorption of non-steroidal anti-inflammatory drugs in the gastrointestinal tract
V - Relationship between drug dosage forms and routes of administration and drugs bioavailability
PL: Dissolution profiles of conventional and prolonged release oral forms of furosemide
VI – Drugs bioavailability determination
PL: Preparation of plasma samples and analysis of oxcarbazepine and its main metabolite (licarbazepine) by HPLC-UV
VII- Bioequivalence and Biodrugs
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Main Bibliography |
Selected articles that will be delivered to students.
To the general aspects of Pharmacology: James M. Ritter, Yoon Kong Loke, Rod J. Flower, Humphrey P. Rang, David Macewan e Graeme Henderson, “Rang & Dale'S Pharmacology”, Ed. ELSEVIER HEALTH SCIENCES, 9th Edition, 2018.
Serafim Guimarães, Daniel Moura, Patrício Soares da Silva, “Terapêutica medicamentosa e suas bases farmacológicas, Manual de Farmacologia e Farmacoterapia”, Ed. Porto Editora, 2014.
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Teaching Methodologies and Assessment Criteria |
Teaching and learning is organized in the form of tutorial classes, seminars and theoretical-practical activities. It is intended that the objectives are developed through the analysis and discussion of articles / slides / book chapters and through the resolution of problems and the analysis of laboratory demonstrations.
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Language |
Portuguese. Tutorial support is available in English.
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