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Tissue Engineering

Code 13547
Year 1
Semester S2
ECTS Credits 6
Workload TP(60H)
Scientific area Biomedical Sciences
Entry requirements Not applicable.
Mode of delivery Face-to-face
Work placements Not applicable
Learning outcomes This course unit gives to the students an overview about the structure, function, properties and production of
materials used in tissue engineering. At the end of this course unit students must be able to:
- Recognise the importance of developing new biomaterials with appropiated properties to their application in
tissue engineering.
- Know the different stages of biomaterials certification for their use in the clinical environment.
- Manipulate basic laboratory equipment.
- Collect, systematize and organize information in order to be aware to discuss a specific theme.
- Recognize their limitations and be aware of the importance of keeping their skills update,
paying special attention to self-learning based on scientific data available.
- Communicate orally and know how to write technical scientific documents.
Syllabus Theoretical program of the course unit

1. Fundamentals of tissue engineering
2. Biomaterials: definition, structure, properties and applications.
3. Biomaterials properties to be used in tissue engineering.
4. Mechanism of tissue growth and differentiation.
5. Tissue culture.
6. Cell and tissue transplantation.
7. Gene therapy.
8. Tissue engineering applied to the different organs of the human body.
9. Organogenesis

Practical programme of of the course unit

- Cell culture in vitro.
- In vitro and in vivo evaluation of materials cytotoxicity
- Acquisition of SEM images.
Main Bibliography 1.Primary bibliography

• Ratner, B.D., Hoffman, A., Schoen, F. and Lemons, J., (2013), “Biomaterials Science, Third Edition: An Introduction to Materials in Medicine”; Elsevier, Canada, ISBN-13: 978-0123746269.
• Fisher, J.P., Mikos, A.G., Bronzino, J.D. and Peterson, D.R., (2017), "Tissue Engineering: Principles and Practices", CRC Press; United States of America, ISBN: 9781138077867.
• Gilbert, S.F. (2016), “Developmental Biology”, Sinauer Associates, United States of America, ISBN-10: 1605354708.
• Hollinger, J.O., (2011) “An introduction to Biomaterials, Second Edition ” CRC Press, United States of America, ISBN: 978-1-4398-1256-3.
• Jorgensen, L. and Nielson, H.M., (2009), “Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines”, Wiley, United Kingdom, ISBN 978-0-470-72338-8.
• Kutz, M., (2002), “Handbook of Materials Selection”, John Wiley & Sons, United States of America, ISBN: 0-471-35924-6.
• Saltzman W. M., (2004) “Tissue Engineering: Engineering principles for the design of replacement organs and tissues”, Oxford University Press, United States of America, ISBN-13: 978-0195141306.
• Smith, W.F., (1998) “Princípios de Ciência e Engenharia dos Materiais”, McGraw-Hill, Portugal, ISBN: 972-8298-68-4.
• Stocum, D. L., (2012), “Regenerative Biology and Medicine”, Elsevier, United States of America, ISBN: 978-0-12-384860-4.
• Callister, W.D., and Rethwisch, D.G. (2012), “Fundamentals of Materials Science and Engineering, An integrated Approach”, 4th edition, John Wiley & Sons, United States of America, ISBN: 978-1-118-06160-2.
• Ziaie, B., Baldi, A. and Atashbar, M.Z., (2010), “Introduction to Micro-/Nanofabrication”, in Bhushan, B. (Ed.) “Springer Handbook of Nanotechnology”, Springer Germany, ISBN 978-3-642-02525-9.

2.Supplementary bibliography

- Scientific articles
Teaching Methodologies and Assessment Criteria In this subject the teaching-learning activities are distributed in theoretical and practical classes. The teacher promotes a great interaction with students in order to ensure their participation and motivation.

Pedagogical methods:
- Theoretical classes involve lectures where different themes are presented;
- In the practical classes, students perform different experimental protocols under the supervision of the
teacher, allowing the consolidation of knowledges taught in the theoretical classes and also the acquisition of
practical skills
- Students perform 2 oral presentations based on scientific articles.

Final Grade: 70% exam+ 30% Oral presentations
Language Portuguese. Tutorial support is available in English.
Last updated on: 2024-03-01

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