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Biochemistry and Cancer Biomarkers

Code 13551
Year 1
Semester S2
ECTS Credits 6
Workload PL(15H)/T(30H)
Scientific area Biomedical Sciences
Entry requirements N/A
Mode of delivery Face-to-face
Work placements Not Applicable
Learning outcomes The curricular unit of Biochemistry and Cancer Biomarkers has the general objective of developing and applying knowledge, attitudes and skills in the understanding of the biochemical meaning of the structure and function of proteins, as well as the molecular mechanisms responsible for the changes in proteins detected in cancer. At the end of this curricular unit the student should be able to: - Describe the classes of biomarkers and explain their importance in clinical practice; Describe protein biosynthesis, and relate structure to function; -Identify, describe and understand post-translational modifications of proteins; - Plan and execute sessions of transmission of knowledge and evaluation of students in the areas of Biomedicine, as well as produce teaching material.
Syllabus Theoretical program
Biomarkers in cancer: Introduction to markers; From DNA to proteins; Prognostic markers and predictive markers of the therapeutic response; Markers used in clinical oncology practice: some applications and limitations. 2. Molecular mechanisms responsible for changes in proteins detected in cancer: Protein biosynthesis; structure and function of proteins; Post-translational modifications; Phosphorylation, Glycosylation. 3. Serological tests in oncology: molecular bases and clinical applications 4. Proteins as therapeutic targets: Biological treatments; antibodies. 5. The teacher as mentor and facilitator of learning: planning the sessions; production of teaching resources; student evaluation.

Practical program
Protein analysis: Protein separation (Chromatography; Gel electrophoresis) and identification by mass spectrometry; Monoclonal and polyclonal antibodies; Immunoenzymatic techniques; Immunohistochemistry and immunocytochemistry; Western Blot.
Main Bibliography D. Voet, J.G. Voet (2011). Biochemistry. 4th ed.,New York: J. Wiley & Sons.
L. M. Sholl, L.J. Hornick (2016) Molecular Pathology: Predictive, Prognostic, and Diagnostic Markers in Tumors, An Issue of Surgical Pathology Clinics, 1st ed., Philadelphia, Elsevier.
G. M. Yousef, S. Jothy (2014) Molecular Testing in Cancer, 1st ed., .,New York: Springer
K. N. Huggett, W. B. Jeffries (2014) An Introduction to Medical Teaching,2nd ed., New York: Springer
Language Portuguese. Tutorial support is available in English.
Last updated on: 2019-06-12

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