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Molecular and Cellular Biology

Code 15844
Year 1
Semester S1
ECTS Credits 6
Workload PL(15H)/T(30H)/TP(15H)
Scientific area Biochemistry
Entry requirements No requirements.
Learning outcomes To Understand the function of cell organelles.
To Acquire knowledge about chemical composition, structural and biomolecules properties.
To Integrate processes and life mechanisms: molecular and cell levels.
To Acquire practical manipulation at biological laboratory techniques.
To Acquire theoretical and practical knowledge about cellular biology and cellular structure.
To Understand basic life cellular mechanisms.
To Understand and integrate the molecular, structural, cellular and physiological basis of organelles.
To Understand the relevance of cellular signalization on communication and cell life.
To Differentiate signalization molecules, cell receptors and signalization types.
To Integrate signalization mechanisms on physiological regulation.
To Describe mitotic, meiotic and apoptotic mechanisms.
To Distinguish by optic microscopic cells on mitotic and meiotic states.
To Discriminate the major differences between apoptotic and necrotic cells.
Syllabus Prokaryotic and eucaryotic cells. Endosymbiotic theory. Cytoskeleton, chromosomes, nuclear envelope and nucleus (elementary notions of gene expression). Dynamics and regulation, nuclear transport, aggregation and disaggregation. Compartmentation, structure and function of the cytoplasmic membrane, hyaloplasm, cytoskeleton, microfilaments, intermediate filaments, microtubules. Mitochondria, chloroplasts, ribosomes, endoplasmic reticulum, Golgi complex: morphology, composition and functions. Lysosomes and peroxisome: structure and functions. Signalization: paracrine, endocrine, autocrine and synaptic. Membrane receptors coupled to G protein and ion channels, tyrosine kinase and phosphatase. Nitric oxide, acetylcholine, and phospholipase C signalization via. CAMP and Ca+2. Mitosis and Meiosis: phases and checkpoints. Apoptosis and effectors. P: Quantification of proteins, amino acids, vitamin C and amido assessment, microscopy, and mitotic phases.
Main Bibliography - Biologia Celular e Molecular, Carlos Azevedo, 4ª edição, Lidel, edições técnicas, Lisboa, 2005.
- Molecular Cell Biology, Lodish et al., 5th edition, W. H. Freeman and Company, 2004.
- Molecular Biology of the Cell, Alberts et al, 3th or 4th Edition, Garland Publishing.
Teaching Methodologies and Assessment Criteria TP and PL classes in face-to-face mode. The final classification of the teaching-learning period (CEA) is calculated according to the following expression: CEA = 65% TP + 35% PL where, (TP) corresponds to the classification obtained in the theoretical-practical component, defined by two frequencies ( F1 and F2) and calculated according to the following expression: TP = 50% F1+ 50% F2. The laboratory practical component (PL) is determined according to the following expression: PL = 60% EP + 35% DL + 5% (A) where, (EP) corresponds to the classification obtained in the practical test (0 to 20 values), (DL) to the classification obtained in the laboratory performance (0 to 20 values); (A) the classification obtained in Assiduity (0 to 20 values). A final grade TP equal to or greater than 9.5 values (arithmetic mean of the two theoretical tests) is required to pass the theoretical component. A final grade PL equal to or greater than 9.5 is required to pass the course unit.
Language Portuguese. Tutorial support is available in English.
Last updated on: 2023-10-09

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