|
Learning outcomes |
Students should acquire the necessary and sufficient knowledge to implement and optimize processes and unit operations common in
Biochemical Engineering, in particular, in cell disintegration, transport phenomena in bioseparation, recovery and separation/purification of
products obtained in bioreactors.
After this Curricular Unit the student should be able to implement, examine and manipulate strategies for cell rupture, recovery, separation and purification of biological products obtained both extracellularly and intracellularly. Consequently, they should be able to describe and discuss the main parameters influencing the performance of unit operations and analytical methods used for solid-liquid separation (filtration, Sedimentation, Flotation, Centrifugation and membrane Technologies) and separation/purification of soluble products (liquid-liquid Extraction, Adsorption, Precipitation, Chromatography Electrophoresis and Lyophilization).
|
|
Main Bibliography |
- Carta, G. and Jungbauer, A. (2020) Protein Chromatography. Process Development and Scale-
Up, 2nd Edition, Wiley-VCH: Weinheim, Germany.
- Ahuja S. (ed.) (2000). Handbook of Bioseparations. Academic Press, San Diego, USA.
- Mulder, M. (1998). Basic Principles of Membrane Technology. Kluwer Academic Publishers, Nederland.
- H.C. Vogel, H.C. and Todaro, C.L. (1997). Fermentation and Biochemical Engineering Handbok: Principles, Process design and Equipment. Noyes Publications, USA.
- Cooke, M. and Poole, C.F. (1996). Encyclopaedia of Separation Science. Academic Press, USA.- Kennedy, J.F., Cabral, J. M.S. (1993). Recovery processes for biological materials, Wiley.
- Kennedy, J.F., Cabral, J.M.S. (eds.) (1993). Recovery Processes for Biological Materials, John Wiley & Sons, Chichester, UK.
- Bailey, J.E. and Ollis, D.F. (1986). Biochemical Engineering Fundamentals. McGraw-Hill, New York, USA.
|