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Cellular and Molecular Biology

Code 9089
Year 1
Semester S1
ECTS Credits 6
Workload PL(15H)/T(30H)/TP(15H)
Scientific area Química e Bioquímica
Entry requirements No requirements.
Mode of delivery Teorical classes by the implementation of a tutorial system and pratical classes in a typical laboratory format.
Learning outcomes To Understand the function of cell organelles.
To Acquire knowledge about chemical composition, structural and biomolecules properties.
To Integrate processes and life mechanisms: molecular and cell levels.
To Acquire pratical manipulation at biological laboratory techniques.
To Acquire teorical and practical knowledge about cellular biology and cellular structure.
To Understand basic life cellular mechanisms.
To Understand and integrate the molecular, structural, cellular and physiological basis of organelles.
To Understand the relevance of cellular signalization on communication and cell life.
To Differentiate signalization molecules, cell receptors and signalization types.
To Integrate signalization mechanisms on physiological regulation.
To Describe mitotic, meiotic and apoptotic mechanisms.
To Distinguish by optic microscopic cells on mitotic and meiotic states.
To Discriminate the major diferences between apoptotic and necrotic cells.
Syllabus Prokaryotic and eucariotic cells. Endosymbiotic theory.
Cytoskeleton, chromosomes, nuclear envelope and nucleus (gene expression, nucleic acid). Dynamics and regulation, nuclear transport, aggregation and disaggregation.
Compartmentation, structure and function of the cytoplasmic membrane, hialoplasma, cytoskeleton, microfilaments, intermediate filaments, microtubules. Mitochondria, chloroplasts, ribosomes, endoplasmic reticulum, Golgi complex: morphology, composition and functions .Lysosomes and peroxisome: structure and functions. Lipids and carbon hydrates.
Signalization: paracrine, endocrine, autocrine and synaptic. Membrane receptors coupled to G protein and ion channels, tyrosine kinase and phosphatase. Nitric oxide, acetylcholine, and phospholipase C signalization via. CAMP and Ca+2. Mitosis and Meiosis: phases and checkpoints. Apoptosis and effectors. P: proteins by spectrophotometric methods, amino acids, vitamin C, rat dissection, microscopy, and mitotic phases.
Main Bibliography - Biologia Celular e Molecular, Carlos Azevedo, 4ª edição, Lidel, edições técnicas, Lisboa, 2005.
- Molecular Cell Biology, Lodish et al., 5th edition, W. H. Freeman and Company, 2004.
- Molecular Biology of the Cell, Alberts et al, 3th or 4th Edition, Garland Publishing.
Teaching Methodologies and Assessment Criteria
Classification of Teaching Learning: (Factor a x 0.35) + (Factor b x 0.65)
Factor a) Practical assessment (final grade greater than or equal to 9.5 points) with a relative weight of 35% in the final classification.
The evaluation includes:
• Classification of the evaluation of the fundamentals of practical classes - 60%
• Laboratory performance through posture and laboratory execution - 35%
• Punctuality - 5%
Final score of the practical grade (PL) = weighted average of the practical evaluation (60%) + Assessment Laboratory performance (35%) + Punctuality (5%)
Failure to pass in practice will imply failure of the curricular unit.
Factor b) Written test with a weight of 60% (minimum mark of 9.5 points). Final mark of 9.5 or more.
This component is subdivided into three frequencies (F1 to F3). Formula: F1+F2+F3/3
Language Portuguese. Tutorial support is available in English.
Last updated on: 2020-01-16

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