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Biomaterials

Code 9121
Year 3
Semester S2
ECTS Credits 6
Workload T(30H)/TP(30H)
Scientific area Bioengenharia
Entry requirements Not applicable.
Mode of delivery Face-to-face
Work placements Not applicable
Learning outcomes This course unit gives to the students an overview about the structure, function, properties andproduction of
materials usedin the manufacture ofmedicaldevices usedin regenerative medicine.

At the end of this course unit students must be able to:
- Be aware of the importance of developing new biomateriais to be used in regenerative medicine.
- Understand the importance of fully characterize biomateriais for biomedical applications. -Know the different stages of biomateriais certification, until they can be used in the clinical environment.
- Use basic laboratory equipment.
- Read and understand scientific documents.
- Recognize their limitations and be aware of the importance of keeping their skills update, paying special
attention to self-learning based on scientific data available.
Syllabus Theoretical program of the course unit

1. Materials and civilization. Materials Classification. State of art of biomaterials and future trends.
2. Materials properties. Characterization assays.
3. Different types of biomaterials: Structure, properties and application examples.
4. Principles of selection of biomaterials. Selection strategies. Lifecycle, re-usability, recyclability and recoverability.
5. Principles of biomaterials selection for their use in biological systems.
6. Different applications of biomaterials in Biology, Biochemistry and Medicine.
7. Relationship between chemical and physical properties of biomaterials and their interactions with biological systems.
8. Tissue Engineering.

Theretical and Practical programme of of the course unit

- Atomic Organization of materials
- Different properties of biomaterials.
- Examples of metal alloys used as biomaterials.
- Polymers used as biomaterials.
- Composite materials used as biomaterials.
Main Bibliography 1. Primary bibliography

• Ratner, B.D., Hoffman, A., Schoen, F. and Lemons, J., (2013), “Biomaterials Science, Third Edition: An Introduction to Materials in Medicine”; Elsevier, Canada, ISBN-13: 978-0123746269.
• Fisher, J.P., Mikos, A.G., Bronzino, J.D. and Peterson, D.R., (2017), "Tissue Engineering: Principles and Practices", CRC Press; United States of America, ISBN: 9781138077867.
• Gilbert, S.F. (2016), “Developmental Biology”, Sinauer Associates, United States of America, ISBN-10: 1605354708.
• Hollinger, J.O., (2011) “An introduction to Biomaterials, Second Edition ” CRC Press, United States of America, ISBN: 978-1-4398-1256-3.
• Jorgensen, L. and Nielson, H.M., (2009), “Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines”, Wiley, United Kingdom, ISBN 978-0-470-72338-8.
• Kutz, M., (2002), “Handbook of Materials Selection”, John Wiley & Sons, United States of America, ISBN: 0-471-35924-6.
• Saltzman W. M., (2004) “Tissue Engineering: Engineering principles for the design of replacement organs and tissues”, Oxford University Press, United States of America, ISBN-13: 978-0195141306.
• Smith, W.F., (1998) “Princípios de Ciência e Engenharia dos Materiais”, McGraw-Hill, Portugal, ISBN: 972-8298-68-4.
• Stocum, D. L., (2012), “Regenerative Biology and Medicine”, Elsevier, United States of America, ISBN: 978-0-12-384860-4.
• Callister, W.D., and Rethwisch, D.G. (2012), “Fundamentals of Materials Science and Engineering, An integrated Approach”, 4th edition, John Wiley & Sons, United States of America, ISBN: 978-1-118-06160-2.

2.Supplementary bibliography

- Scientific articles.
Teaching Methodologies and Assessment Criteria In this subject the teaching-learning activities are distributed in theoretical and practical classes. The teacher promotes a great interaction with students in order to ensure their participation and motivation.

Pedagogical methods:
- Theoretical classes involve lectures where different themes are presented;
- In the practical classes, students perform different experimental protocols under the supervision of the teacher, allowing the consolidation of knowledges taught in the theoretical classes and also the acquisition of practical skills


Evaluation methods and criteria

Teaching learning classification
Final Score = (Frequency 1 x 0.5) + (Frequency 2 x 0.5)

Classification of the exam
Final Score = score obtained in the final exam.
Language Portuguese. Tutorial support is available in English.
Last updated on: 2023-06-11

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