| Code |
12826
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| Year |
3
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| Semester |
S1
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| ECTS Credits |
6
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| Workload |
PL(15H)/T(30H)/TP(15H)
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| Scientific area |
Biochemistry
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Entry requirements |
Not applicable
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Mode of delivery |
Classroom
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Work placements |
Not applicable
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Learning outcomes |
The curricular unit aims to impart to students the basic knowledge, both on the development, structure, and functioning of the innate and adaptive components of the immune system in humans, as well as on the humoral and cellular responses, always trying to integrate the acquired concepts in a current immunopathological context.
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Syllabus |
THEORETICAL CLASSROOMS
1. OVERVIEW OF THE IMMUNE SYSTEM
1.1. Important Concepts for Understanding the Immune Response
1.2. Cells, Organs, and Microenvironments of the Immune System
1.3. Antigen Recognition and Response
2. INNATE IMMUNITY
2.1. Cells and Innate Response Receptors
2.2. Interactions between Innate and Adaptive Immune Systems
2.3. The Major Histocompatibility Complex
2.4. Innate Effector Mechanisms
2.5. The Complement System
3. ADAPTIVE IMMUNITY
3.1. T Cell Development, Activation, and Differentiation
3.2. B Cell Development, Activation, and Differentiation
3.3. Effector Responses: Antibody and Cell-Mediated Immunity
LABORATORY CLASSROOMS:
1. Lymphocyte isolation from blood samples
2. Morphological and phenotypical analysis by flow cytometry
THEORETICAL-PRACTICAL CLASSROOMS
1. Resolution of exercises and quizzes
2. Elaboration and presentation of a scientific work
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Main Bibliography |
Main Bibliography:
- Kuby Immunology, 8th Edition. W.H. Freeman & and Company, 2019 (Macmillan Education)
Complementary bibliography:
- Fundamentos de Imunologia, 2ª Edição, 2012. LIDEL Ediçoes Técnicas.
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Teaching Methodologies and Assessment Criteria |
During the theoretical classrooms, the teaching methodologies include presentation of contents using audiovisual media (PowerPoint presentations), including short videos and animations. In order to students understand the relevance of the contents taught, interactive Quizzes related with the topics taught and resolution of worksheets will be used. During the laboratorial classrooms, students have the opportunity to perform laboratory techniques that allow to visualize peripheral blood lymphocytes and some of the receptors that distinguish them. The theoretical-practical classrooms are basically tutorials where groups of 2-3 students carry out a scientific search of articles in the PubMed database. The objective is to elaborate a small research work focused on a disease that afflicts the developed countries, for example diabetes, atherosclerosis, neurodegeneration, rheumatoid arthritis, etc., and its relationship with the immune system.
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Language |
Portuguese. Tutorial support is available in English.
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